Copy number variations in DCC/18q and ERBB2/17q are associated with disease‐free survival in microsatellite stable colon cancer

We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II–III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p,...

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Veröffentlicht in:	International journal of cancer 2017-04, Vol.140 (7), p.1653-1661
Hauptverfasser:	Sefrioui, David, Vermeulin, Thomas, Blanchard, France, Chapusot, Caroline, Beaussire, Ludivine, Armengol‐Debeir, Laura, Sesboué, Richard, Gangloff, Alice, Hebbar, Mohamed, Copin, Marie‐Christine, Houivet, Estelle, Schwarz, Lilian, Clatot, Florian, Tuech, Jean‐Jacques, Bénichou, Jacques, Martin, Laurent, Bouvier, Anne‐Marie, Sabourin, Jean‐Christophe, Sarafan‐Vasseur, Nasrin, Frébourg, Thierry, Lepage, Côme, Michel, Pierre, Di Fiore, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Cancer Carcinoma - genetics Carcinoma - mortality Carcinoma - pathology Chromosomal instability Colon Cancer Colonic Neoplasms - genetics Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colorectal cancer Copy Number Variation DCC Receptor Disease-Free Survival DNA Copy Number Variations DNA Mutational Analysis Female Humans Life Sciences Loss of Heterozygosity Male Medical prognosis Medical research Microsatellite Repeats Microstellite Stable Middle Aged Multivariate analysis Neoplasm Metastasis Neoplasm Recurrence, Local - genetics Phenotype Polymerase Chain Reaction Prognosis Proportional Hazards Models Prospective Studies Proto-Oncogene Proteins B-raf - genetics Receptor, ErbB-2 - genetics Receptors, Cell Surface - genetics Treatment Outcome Tumor Suppressor Proteins - genetics
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Zusammenfassung:	We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in Stage II–III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end‐point was the impact of the CNVs on the 4‐year disease‐free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% Stage II patients versus 31% Stage III patients (p
ISSN:	0020-7136 1097-0215
DOI:	10.1002/ijc.30584