Four-Component Photoredox-Mediated Azidoalkoxy-trifluoromethylation of Alkenes

Four-Component Photoredox-Mediated Azidoalkoxy-trifluoromethylation of Alkenes

We report herein an efficient four-component photoredox-catalyzed reaction. Under the optimized conditions using [Ru­(bpy)3(PF6)2] as the photocatalyst, a wide range of terminal and internal alkenes can efficiently undergo azidoalkoxy-trifluoromethylation in the presence of Umemoto’s reagent, carbon...

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Veröffentlicht in:Organic letters 2019-08, Vol.21 (15), p.6005-6010
Hauptverfasser: Levitre, Guillaume, Dagousset, Guillaume, Anselmi, Elsa, Tuccio, Béatrice, Magnier, Emmanuel, Masson, Géraldine
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Organic chemistry
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Zusammenfassung:We report herein an efficient four-component photoredox-catalyzed reaction. Under the optimized conditions using [Ru­(bpy)3(PF6)2] as the photocatalyst, a wide range of terminal and internal alkenes can efficiently undergo azidoalkoxy-trifluoromethylation in the presence of Umemoto’s reagent, carbonyl compound, and TMSN3, giving rise to original and highly complex molecules in a single operation.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b02152