Bilateral Wada test: Amobarbital or propofol?

Abstract Purpose The Wada test is still the gold standard procedure to predict language and memory deficits before temporal lobe epilepsy surgery. As amobarbital was no longer available, our aim was to validate propofol as an alternative. Method We retrospectively studied 47 patients who underwent a...

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Veröffentlicht in:Seizure (London, England) England), 2014-02, Vol.23 (2), p.122-128
Hauptverfasser: Curot, J, Denuelle, M, Busigny, T, Barragan-Jason, G, Kany, M, Tall, P, Marlat, F, Fabre, N, Valton, L
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container_end_page 128
container_issue 2
container_start_page 122
container_title Seizure (London, England)
container_volume 23
creator Curot, J
Denuelle, M
Busigny, T
Barragan-Jason, G
Kany, M
Tall, P
Marlat, F
Fabre, N
Valton, L
description Abstract Purpose The Wada test is still the gold standard procedure to predict language and memory deficits before temporal lobe epilepsy surgery. As amobarbital was no longer available, our aim was to validate propofol as an alternative. Method We retrospectively studied 47 patients who underwent a bilateral intracarotid procedure, performed with amobarbital (18), or propofol (29), between 2000 and 2010 during the preoperative evaluation of temporal lobe epilepsy. Results The number of patients experiencing an adverse event (mostly transient disturbance of consciousness or benign ocular symptoms) during both injections did not differ significantly between amobarbital and propofol. Hemispheric dominance was successfully determined in 96.5% patients with propofol vs. 94.4% with amobarbital for language, and in 72.4% under propofol vs. 77.7% under amobarbital for memory with no significant difference between groups. Conclusion Propofol can be used for the Wada test with an efficacy and safety comparable to amobarbital.
doi_str_mv 10.1016/j.seizure.2013.10.009
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As amobarbital was no longer available, our aim was to validate propofol as an alternative. Method We retrospectively studied 47 patients who underwent a bilateral intracarotid procedure, performed with amobarbital (18), or propofol (29), between 2000 and 2010 during the preoperative evaluation of temporal lobe epilepsy. Results The number of patients experiencing an adverse event (mostly transient disturbance of consciousness or benign ocular symptoms) during both injections did not differ significantly between amobarbital and propofol. Hemispheric dominance was successfully determined in 96.5% patients with propofol vs. 94.4% with amobarbital for language, and in 72.4% under propofol vs. 77.7% under amobarbital for memory with no significant difference between groups. Conclusion Propofol can be used for the Wada test with an efficacy and safety comparable to amobarbital.</description><identifier>ISSN: 1059-1311</identifier><identifier>EISSN: 1532-2688</identifier><identifier>DOI: 10.1016/j.seizure.2013.10.009</identifier><identifier>PMID: 24252808</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Amobarbital ; Amobarbital - adverse effects ; Anesthetics - adverse effects ; Brain - drug effects ; Brain - physiopathology ; Cognitive science ; Consciousness - drug effects ; Epilepsy, Temporal Lobe - physiopathology ; Epilepsy, Temporal Lobe - surgery ; Female ; Functional Laterality ; Humans ; Language ; Male ; Memory ; Memory - drug effects ; Memory - physiology ; Middle Aged ; Neurology ; Neuropsychological Tests ; Neuroscience ; Preoperative Care - adverse effects ; Preoperative Care - methods ; Propofol ; Propofol - adverse effects ; Retrospective Studies ; Temporal epilepsy ; Visual Perception - drug effects ; Wada ; Young Adult</subject><ispartof>Seizure (London, England), 2014-02, Vol.23 (2), p.122-128</ispartof><rights>British Epilepsy Association</rights><rights>2013 British Epilepsy Association</rights><rights>Copyright © 2013 British Epilepsy Association. 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source MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Adolescent
Adult
Amobarbital
Amobarbital - adverse effects
Anesthetics - adverse effects
Brain - drug effects
Brain - physiopathology
Cognitive science
Consciousness - drug effects
Epilepsy, Temporal Lobe - physiopathology
Epilepsy, Temporal Lobe - surgery
Female
Functional Laterality
Humans
Language
Male
Memory
Memory - drug effects
Memory - physiology
Middle Aged
Neurology
Neuropsychological Tests
Neuroscience
Preoperative Care - adverse effects
Preoperative Care - methods
Propofol
Propofol - adverse effects
Retrospective Studies
Temporal epilepsy
Visual Perception - drug effects
Wada
Young Adult
title Bilateral Wada test: Amobarbital or propofol?
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