Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation carriers

QT and Tp/Te intervals were longer in patients with LQT1 (n = 67) than in nonaffected subjects (n = 52) but did not differentiate symptomatic (n = 21) from asymptomatic patients (n = 46). At fast heart rate, the time to accumulate the last part of total T-wave area (the t50-97 interval) was longer i...

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Veröffentlicht in:	The American journal of cardiology 2005-02, Vol.95 (3), p.406-409
Hauptverfasser:	Extramiana, Fabrice, Denjoy, Isabelle, Badilini, Fabio, Chabani, Iheb, Neyroud, Nathalie, Berthet, Myriam, Fressard, Véronique, Guicheney, Pascale, Beaufils, Philippe, Leenhardt, Antoine, Coumel, Philippe, Maison-Blanche, Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Cardiology Cardiology and cardiovascular system Cardiology. Vascular system Carrier State Chi-Square Distribution Child Electrocardiography, Ambulatory Female General aspects. Genetic counseling Genotype Heart Heart Rate Heart Rate - physiology Human health and pathology Humans Life Sciences Long QT Syndrome Long QT Syndrome - genetics Long QT Syndrome - physiopathology Male Medical genetics Medical sciences Middle Aged Mutation Mutation - genetics
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Zusammenfassung:	QT and Tp/Te intervals were longer in patients with LQT1 (n = 67) than in nonaffected subjects (n = 52) but did not differentiate symptomatic (n = 21) from asymptomatic patients (n = 46). At fast heart rate, the time to accumulate the last part of total T-wave area (the t50-97 interval) was longer in symptomatic carriers compared with asymptomatic patients (119 ± 19 vs 106 ± 15 ms, p
ISSN:	0002-9149 1879-1913
DOI:	10.1016/j.amjcard.2004.09.045