Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice

We have investigated the role of somatostatin receptor subtypes sst2 and sst4 in limbic seizures and glutamate‐mediated neurotransmission in mouse hippocampus. As compared to wild‐type littermates, homozygous mice lacking sst2 receptors showed a 52% reduction in EEG ictal activity induced by intrahi...

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Veröffentlicht in:	The European journal of neuroscience 2002-09, Vol.16 (5), p.843-849
Hauptverfasser:	Moneta, D., Richichi, C., Aliprandi, M., Dournaud, P., Dutar, P., Billard, J. M., Carlo, A. S., Viollet, C., Hannon, J. P., Fehlmann, D., Nunn, C., Hoyer, D., Epelbaum, J., Vezzani, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cyclic AMP - metabolism Disease Susceptibility EEG Electroencephalography Electrophysiology epilepsy Epilepsy - metabolism hippocampus Hippocampus - metabolism Hippocampus - physiopathology Life Sciences Male Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Neurons and Cognition neuropeptides Rats Rats, Sprague-Dawley Receptors, Somatostatin - genetics Receptors, Somatostatin - metabolism Seizures - metabolism Seizures - physiopathology Synaptic Transmission
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Zusammenfassung:	We have investigated the role of somatostatin receptor subtypes sst2 and sst4 in limbic seizures and glutamate‐mediated neurotransmission in mouse hippocampus. As compared to wild‐type littermates, homozygous mice lacking sst2 receptors showed a 52% reduction in EEG ictal activity induced by intrahippocampal injection of 30 ng kainic acid (P
ISSN:	0953-816X 1460-9568
DOI:	10.1046/j.1460-9568.2002.02146.x