Comparison of the removal of uraemic toxins with medium cut-off and high-flux dialysers: a randomized clinical trial

Abstract Background Accumulation of middle-weight uraemic toxins in haemodialysis (HD) patients results in increased morbidity and mortality. Whether medium cut-off HD (MCO-HD) improves removal of middle-weight uraemic toxins remains to be demonstrated. Methods This cross-over prospective study incl...

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Veröffentlicht in:Nephrology, dialysis, transplantation dialysis, transplantation, 2020-02, Vol.35 (2), p.328-335
Hauptverfasser: Belmouaz, Mohamed, Bauwens, Marc, Hauet, Thierry, Bossard, Valentin, Jamet, Pierre, Joly, Florent, Chikhi, Elise, Joffrion, Sandrine, Gand, Elise, Bridoux, Frank
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Sprache:eng
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Zusammenfassung:Abstract Background Accumulation of middle-weight uraemic toxins in haemodialysis (HD) patients results in increased morbidity and mortality. Whether medium cut-off HD (MCO-HD) improves removal of middle-weight uraemic toxins remains to be demonstrated. Methods This cross-over prospective study included 40 patients randomly assigned to receive either 3 months of MCO-HD followed by 3 months of high-flux HD (HF-HD), or vice versa. The primary endpoint was myoglobin reduction ratio (RR) after 3 months of MCO-HD. Secondary endpoints were the effect of MCO-HD on other middle-weight toxins and protein-bound toxins, and on parameters of nutrition, inflammation, anaemia and oxidative stress. Results Compared with HF-HD, MCO-HD provided higher mean RR of myoglobin (36 ± 8 versus 57 ± 13%, P 
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfz189