Increased affinity of ghrelin-reactive immunoglobulins in obese Zucker rats

Highlights • Ghrelin is an acylated peptide hormone stimulating food intake and adiposity; • Previous data showed: i) ghrelin is protected from degradation by plasma IgG; • ii) plasma IgG from obese humans and mice enhanced ghrelin’s orexigenic effect; • iii) obese humans and mice display increased...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2017-07, Vol.39-40, p.98-99
Hauptverfasser:	Lucas, Nicolas, Legrand, Romain, Breton, Jonathan, Déchelotte, Pierre, Fetissov, Sergueï O
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Escherichia coli Food and Nutrition Gastroenterology and Hepatology Ghrelin Ghrelin - blood Ghrelin - immunology Immunoglobulin G - blood Immunoglobulins Life Sciences Male Metabolism Mutation Nutrition Obesity Obesity - immunology Plasma Rats Rats, Zucker Rodents Studies
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Beschreibung
Zusammenfassung:	Highlights • Ghrelin is an acylated peptide hormone stimulating food intake and adiposity; • Previous data showed: i) ghrelin is protected from degradation by plasma IgG; • ii) plasma IgG from obese humans and mice enhanced ghrelin’s orexigenic effect; • iii) obese humans and mice display increased affinity of plasma IgG for ghrelin; • Here we show that affinity of plasma IgG for ghrelin is increased in obese Zucker rats.
ISSN:	0899-9007 1873-1244
DOI:	10.1016/j.nut.2016.11.007