Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling

An atropo-diastereoselective synthesis with dr up to 98/2 towards the biaryl subunit of vancomycin based on the use of enantiopure β-hydroxysulfoxide derivatives as novel chiral auxiliary is reported.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Organic & biomolecular chemistry 2012-05, Vol.10 (20), p.4095-4102
Hauptverfasser:	Leermann, Timo, Broutin, Pierre-Emmanuel, Leroux, Frédéric R, Colobert, Françoise
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Molecular Structure Organic chemistry Stereoisomerism Vancomycin - analogs & derivatives Vancomycin - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	An atropo-diastereoselective synthesis with dr up to 98/2 towards the biaryl subunit of vancomycin based on the use of enantiopure β-hydroxysulfoxide derivatives as novel chiral auxiliary is reported.
ISSN:	1477-0520 1477-0539
DOI:	10.1039/c2ob25373a