Polymorphism in the Microglial Cell-Mobilizing CX3CR1 Gene Is Associated With Survival in Patients With Glioblastoma

Few reliable prognostic molecular markers have been characterized for glioblastoma multiforme (GBM), considered the deadliest of human cancers. We hypothesized that genetic polymorphisms in chemokines and their receptors, which together control microglial cell mobilization, may influence survival. D...

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Veröffentlicht in:	Journal of clinical oncology 2008-12, Vol.26 (36), p.5957-5964
Hauptverfasser:	RODERO, Mathieu, MARIE, Yannick, DELATTRE, Jean-Yves, DEBRE, Patrice, SANSON, Marc, COMBADIERE, Christophe, COUDERT, Mathieu, BLONDET, Emmeline, MOKHTARI, Karima, ROUSSEAU, Audrey, RAOUL, William, CARPENTIER, Catherine, SENNLAUB, Florian, DETERRE, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Biological and medical sciences Cancer Female Genotype Glioblastoma - genetics Glioblastoma - mortality Humans Immunohistochemistry Life Sciences Male Medical sciences Microglia - cytology Middle Aged Neurology Polymorphism, Genetic Prospective Studies Receptors, Chemokine - genetics Retrospective Studies Tumors Tumors of the nervous system. Phacomatoses
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Zusammenfassung:	Few reliable prognostic molecular markers have been characterized for glioblastoma multiforme (GBM), considered the deadliest of human cancers. We hypothesized that genetic polymorphisms in chemokines and their receptors, which together control microglial cell mobilization, may influence survival. Distributions of one polymorphism of the chemokine CCL2 (-2518A
ISSN:	0732-183X 1527-7755
DOI:	10.1200/JCO.2008.17.2833