Synthesis and mannose receptor-Mediated uptake of clustered glycomimetics by human dendritic cells: effect of charge

Effect of charge and shape of multivalent lysine-based cluster glycomimetics on their mannose receptor-mediated uptake by human dendritic cells has been evaluated: The capture is strongly affected by the shape of the ligands. The effect of charge is less pronounced although positive charges on the l...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2002-10, Vol.12 (19), p.2723-2727
Hauptverfasser:	Angyalosi, Gerhild, Grandjean, Cyrille, Lamirand, Mélanie, Auriault, Claude, Gras-Masse, Hélène, Melnyk, Oleg
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Chemical Sciences Dendritic Cells - drug effects Flow Cytometry Fluorescein Fundamental and applied biological sciences. Psychology Fundamental immunology Glucose - pharmacology Immunobiology Lectins, C-Type Ligands Mannose-Binding Lectins Miscellaneous Molecular Mimicry Organic chemistry Quinic Acid - chemistry Receptors, Cell Surface - drug effects Regulatory factors and their cellular receptors Shikimic Acid - pharmacology
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