Biological modeling of mucus to modulate mucus barriers

A recent study using a transgenic mouse, whose intestinal mucus contains a molecule made of 12 copies of a domain found in many gelling mucins, demonstrates that it is possible to strengthen mucus properties in situ, leading to promising new treatment strategies in diseases in which the mucosal barr...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2016-02, Vol.310 (4), p.G225-G227
Hauptverfasser:	Desseyn, Jean-Luc, Gouyer, Valérie, Gottrand, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body fluids Gastrointestinal Microbiome - immunology Intestinal Mucosa - metabolism Life Sciences Mucin-2 - metabolism Mucus - metabolism Rodents Tight Junctions - physiology Transgenic animals
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Beschreibung
Zusammenfassung:	A recent study using a transgenic mouse, whose intestinal mucus contains a molecule made of 12 copies of a domain found in many gelling mucins, demonstrates that it is possible to strengthen mucus properties in situ, leading to promising new treatment strategies in diseases in which the mucosal barrier is impaired.
ISSN:	0193-1857 1522-1547 1522-1547
DOI:	10.1152/ajpgi.00274.2015