Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans , has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a fu...

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Veröffentlicht in:Organic Chemistry Frontiers 2017-01, Vol.4 (12), p.2380-2386
Hauptverfasser: Saint-Auret, Sarah, Abdelkafi, Hajer, Le Nouen, Didier, Bisseret, Philippe, Blanchard, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Catalysis
Chemical reactions
Chemical Sciences
Chemical synthesis
Exotoxins
Forging
Hydroboration
Mycobacterium ulcerans
Organic chemistry
Palladium
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Zusammenfassung:Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans , has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a functionalized and sterically demanding 1,1-disubstituted exo -alkene. The full account of these investigations is discussed.
ISSN:2052-4129
2052-4110
2052-4129
2052-4110
DOI:10.1039/C7QO00608J