From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase
This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With...
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| Veröffentlicht in: | Natural product reports 2002-02, Vol.19 (1), p.60-69 |
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| creator | Teplyakov, Alexey Leriche, Caroline Obmolova, Galya Badet, Bernard Badet-Denisot, Marie-Ange |
| description | This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes. |
| doi_str_mv | 10.1039/b103713g |
| format | Article |
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The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.</description><identifier>ISSN: 0265-0568</identifier><identifier>EISSN: 1460-4752</identifier><identifier>DOI: 10.1039/b103713g</identifier><identifier>PMID: 11902440</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Ammonia - metabolism ; Animals ; Biochemistry ; Biochemistry, Molecular Biology ; Catalysis ; Chemical Sciences ; Crystallography, X-Ray ; Diabetes Mellitus, Type 2 - enzymology ; Escherichia coli - enzymology ; Fungi - enzymology ; Glucosamine - analogs & derivatives ; Glucosamine - biosynthesis ; Glucose - chemistry ; Glucose - metabolism ; Glucose-6-Phosphate - analogs & derivatives ; Glucose-6-Phosphate - biosynthesis ; Glutamine - chemistry ; Glutamine - metabolism ; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - chemistry ; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - metabolism ; Humans ; Hydrolysis ; Life Sciences ; Mice ; Molecular Structure ; Nitrogen - chemistry ; Nitrogen - metabolism ; Organic chemistry ; Protein Conformation ; Rats ; Structural Biology ; Structure-Activity Relationship</subject><ispartof>Natural product reports, 2002-02, Vol.19 (1), p.60-69</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b0cc840375599319efe217edfb74a528c0f2b1ad19729b6d60f032513da2322c3</citedby><orcidid>0000-0003-3417-6330</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2818,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11902440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-02144712$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Teplyakov, Alexey</creatorcontrib><creatorcontrib>Leriche, Caroline</creatorcontrib><creatorcontrib>Obmolova, Galya</creatorcontrib><creatorcontrib>Badet, Bernard</creatorcontrib><creatorcontrib>Badet-Denisot, Marie-Ange</creatorcontrib><title>From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase</title><title>Natural product reports</title><addtitle>Nat Prod Rep</addtitle><description>This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. 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Leriche, Caroline ; Obmolova, Galya ; Badet, Bernard ; Badet-Denisot, Marie-Ange</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b0cc840375599319efe217edfb74a528c0f2b1ad19729b6d60f032513da2322c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Ammonia - metabolism</topic><topic>Animals</topic><topic>Biochemistry</topic><topic>Biochemistry, Molecular Biology</topic><topic>Catalysis</topic><topic>Chemical Sciences</topic><topic>Crystallography, X-Ray</topic><topic>Diabetes Mellitus, Type 2 - enzymology</topic><topic>Escherichia coli - enzymology</topic><topic>Fungi - enzymology</topic><topic>Glucosamine - analogs & derivatives</topic><topic>Glucosamine - biosynthesis</topic><topic>Glucose - chemistry</topic><topic>Glucose - metabolism</topic><topic>Glucose-6-Phosphate - analogs & derivatives</topic><topic>Glucose-6-Phosphate - biosynthesis</topic><topic>Glutamine - chemistry</topic><topic>Glutamine - metabolism</topic><topic>Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - chemistry</topic><topic>Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - metabolism</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>Life Sciences</topic><topic>Mice</topic><topic>Molecular Structure</topic><topic>Nitrogen - chemistry</topic><topic>Nitrogen - metabolism</topic><topic>Organic chemistry</topic><topic>Protein Conformation</topic><topic>Rats</topic><topic>Structural Biology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teplyakov, Alexey</creatorcontrib><creatorcontrib>Leriche, Caroline</creatorcontrib><creatorcontrib>Obmolova, Galya</creatorcontrib><creatorcontrib>Badet, Bernard</creatorcontrib><creatorcontrib>Badet-Denisot, Marie-Ange</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Natural product reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teplyakov, Alexey</au><au>Leriche, Caroline</au><au>Obmolova, Galya</au><au>Badet, Bernard</au><au>Badet-Denisot, Marie-Ange</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase</atitle><jtitle>Natural product reports</jtitle><addtitle>Nat Prod Rep</addtitle><date>2002-02</date><risdate>2002</risdate><volume>19</volume><issue>1</issue><spage>60</spage><epage>69</epage><pages>60-69</pages><issn>0265-0568</issn><eissn>1460-4752</eissn><abstract>This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. 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| source | Royal Society of Chemistry Journals Archive (1841-2007); MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Ammonia - metabolism Animals Biochemistry Biochemistry, Molecular Biology Catalysis Chemical Sciences Crystallography, X-Ray Diabetes Mellitus, Type 2 - enzymology Escherichia coli - enzymology Fungi - enzymology Glucosamine - analogs & derivatives Glucosamine - biosynthesis Glucose - chemistry Glucose - metabolism Glucose-6-Phosphate - analogs & derivatives Glucose-6-Phosphate - biosynthesis Glutamine - chemistry Glutamine - metabolism Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - chemistry Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - metabolism Humans Hydrolysis Life Sciences Mice Molecular Structure Nitrogen - chemistry Nitrogen - metabolism Organic chemistry Protein Conformation Rats Structural Biology Structure-Activity Relationship |
| title | From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase |
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