From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase

This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With...

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Veröffentlicht in:	Natural product reports 2002-02, Vol.19 (1), p.60-69
Hauptverfasser:	Teplyakov, Alexey, Leriche, Caroline, Obmolova, Galya, Badet, Bernard, Badet-Denisot, Marie-Ange
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia - metabolism Animals Biochemistry Biochemistry, Molecular Biology Catalysis Chemical Sciences Crystallography, X-Ray Diabetes Mellitus, Type 2 - enzymology Escherichia coli - enzymology Fungi - enzymology Glucosamine - analogs & derivatives Glucosamine - biosynthesis Glucose - chemistry Glucose - metabolism Glucose-6-Phosphate - analogs & derivatives Glucose-6-Phosphate - biosynthesis Glutamine - chemistry Glutamine - metabolism Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - chemistry Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - metabolism Humans Hydrolysis Life Sciences Mice Molecular Structure Nitrogen - chemistry Nitrogen - metabolism Organic chemistry Protein Conformation Rats Structural Biology Structure-Activity Relationship
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Zusammenfassung:	This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes.
ISSN:	0265-0568 1460-4752
DOI:	10.1039/b103713g