Design, synthesis, activity evaluation and QSAR studies of novel antimalarial 1,2,3-triazolo-β-lactam derivatives

Design, synthesis, activity evaluation and QSAR studies of novel antimalarial 1,2,3-triazolo-β-lactam derivatives

This paper describes the synthesis of some new β-lactam derivatives containing the 1,2,3-triazole moiety. All the compounds were evaluated for their in vitro antimicrobial and antimalarial activities. Moderate to excellent antimalarial activities were encountered. The results showed that compounds 5...

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Veröffentlicht in:Journal of the Iranian Chemical Society 2018-06, Vol.15 (6), p.1311-1326
Hauptverfasser: Jarrahpour, Aliasghar, Aye, Malihe, Rad, Javad Ameri, Yousefinejad, Saeed, Sinou, Véronique, Latour, Christine, Brunel, Jean Michel, Turos, Edward
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Analytical Chemistry
Biochemistry
Chemical synthesis
Chemistry
Chemistry and Materials Science
Derivatives
Inorganic Chemistry
Life Sciences
Organic Chemistry
Original Paper
Physical Chemistry
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Zusammenfassung:This paper describes the synthesis of some new β-lactam derivatives containing the 1,2,3-triazole moiety. All the compounds were evaluated for their in vitro antimicrobial and antimalarial activities. Moderate to excellent antimalarial activities were encountered. The results showed that compounds 5a , 5c , 5f , 5i exhibited the most potent antimalarial activity with IC 50 values of 0.85, 
ISSN:1735-207X
1735-2428
DOI:10.1007/s13738-018-1330-2