Bioengineered 3D Models for Studying Human Cell–Tuberculosis Interactions

In vivo animal models have intrinsic limitations for studying relationships between tuberculosis and its host and there is a need for alternative, in vitro cellular models. A microsphere-based 3D in vitro culture system of Mycobacterium tuberculosis -infected human blood mononuclear cells was report...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2017-04, Vol.25 (4), p.245-246
Hauptverfasser:	Benmerzoug, Sulayman, Quesniaux, Valerie F.J
Format:	Artikel
Sprache:	eng
Schlagworte:	3-D technology Animal models Animals bioelectrospray Bioengineering CD4-Positive T-Lymphocytes - immunology Cell Communication - immunology Cell culture Cell Culture Techniques - methods Cells, Cultured extracellular matrix granuloma Host-pathogen interactions Host-Pathogen Interactions - immunology Humans Immunology in vitro 3D cell model Internal Medicine Leukocytes (mononuclear) Life Sciences Macrophages - immunology Mice microsphere Microspheres Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Studies Three dimensional models Tuberculoma - microbiology Tuberculoma - pathology Tuberculosis Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - pathology Tumor Necrosis Factor-alpha - immunology
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Beschreibung
Zusammenfassung:	In vivo animal models have intrinsic limitations for studying relationships between tuberculosis and its host and there is a need for alternative, in vitro cellular models. A microsphere-based 3D in vitro culture system of Mycobacterium tuberculosis -infected human blood mononuclear cells was reported to address specific aspects of host–pathogen interactions.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2017.02.009