Redox tunable delivery systems: sweet block copolymer micelles via thiol-(bromo)maleimide conjugation

Redox tunable delivery systems: sweet block copolymer micelles via thiol-(bromo)maleimide conjugation

Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with dif...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (82), p.12202-12205
Hauptverfasser: Petrelli, Antoine, Borsali, Redouane, Fort, Sébastien, Halila, Sami
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous solutions
Block copolymers
Chemical Sciences
Conjugation
Delivery systems
Micelles
Polycaprolactone
Sweets
Synthesis (chemistry)
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Zusammenfassung:Oligosaccharide-based block copolymers (OBCPs) are synthesized by thiol click conjugation using reducing-end thiol-containing xyloglucooligosaccharides and maleimide- or bromomaleimide-terminated polycaprolactone. The self-assembled OBCPs in aqueous solution lead to redox-sensitive micelles with different responsiveness. This distinguishing feature allows us to control the release of entrapped hydrophobic Nile red by mixing both OBCPs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07136h