A physico-chemical investigation of fluorine-enriched quinolines

Quinoline derivatives bearing fluoroalkyl groups at both 2 and 4 positions are scarcely described in the literature. Nevertheless, the addition of fluorine onto the quinoline core might bring about new interesting physico-chemical properties. To confirm this hypothesis a homogenous series of 2,4-bis(fluoroalkyl)-substituted quinolines was synthesized under mild reaction conditions and their physico-chemical properties were thoroughly investigated by various techniques to illustrate their potential usefulness as new building blocks for applications ranging from organic chemistry to materials science.