An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression
The olfactory bulbectomized (OB) rat is a well-accepted animal model of depression. The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ven...
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| Veröffentlicht in: | Brain research 2000-10, Vol.879 (1), p.193-199 |
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| creator | Wrynn, Aileen S. Mac Sweeney, Clı́ona P. Franconi, Florence Lemaire, Laurent Pouliquen, Daniel Herlidou, Sandra Leonard, Brian E. Gandon, Jean-Marc de Certaines, Jacques D. |
| description | The olfactory bulbectomized (OB) rat is a well-accepted animal model of depression. The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ventricular enlargement was also evident in OB animals. These alterations have implications with regard to the face and construct validity of this model. |
| doi_str_mv | 10.1016/S0006-8993(00)02619-6 |
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The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ventricular enlargement was also evident in OB animals. These alterations have implications with regard to the face and construct validity of this model.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>EISSN: 0006-8993</identifier><identifier>DOI: 10.1016/S0006-8993(00)02619-6</identifier><identifier>PMID: 11011022</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adult and adolescent clinical studies ; Amygdala - physiology ; Amygdala - physiopathology ; Animal model of depression ; Animals ; Bioengineering ; Biological and medical sciences ; Brain - physiology ; Brain - physiopathology ; Caudate Nucleus - physiology ; Caudate Nucleus - physiopathology ; Cerebral Cortex - physiology ; Cerebral Cortex - physiopathology ; Cerebral Ventricles - physiology ; Cerebral Ventricles - physiopathology ; Degeneration ; Depression ; Depression - physiopathology ; Disease Models, Animal ; Hippocampus - physiology ; Hippocampus - physiopathology ; Imaging ; Life Sciences ; Magnetic Resonance Imaging ; Medical sciences ; Mood disorders ; MRI ; Olfactory Bulb - physiology ; Olfactory bulbectomy ; Psychology. 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Psychiatry ; Rats ; Reference Values ; Ventricular enlargement</subject><ispartof>Brain research, 2000-10, Vol.879 (1), p.193-199</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2000 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-8c31e6ba34b987e1be9121a27cd59e957c9acc6cb62dc3b4d77c981c38d281853</citedby><cites>FETCH-LOGICAL-c455t-8c31e6ba34b987e1be9121a27cd59e957c9acc6cb62dc3b4d77c981c38d281853</cites><orcidid>0000-0001-6725-0803 ; 0000-0002-3765-0889 ; 0000-0002-1308-9345</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(00)02619-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1533228$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11011022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02100291$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Wrynn, Aileen S.</creatorcontrib><creatorcontrib>Mac Sweeney, Clı́ona P.</creatorcontrib><creatorcontrib>Franconi, Florence</creatorcontrib><creatorcontrib>Lemaire, Laurent</creatorcontrib><creatorcontrib>Pouliquen, Daniel</creatorcontrib><creatorcontrib>Herlidou, Sandra</creatorcontrib><creatorcontrib>Leonard, Brian E.</creatorcontrib><creatorcontrib>Gandon, Jean-Marc</creatorcontrib><creatorcontrib>de Certaines, Jacques D.</creatorcontrib><title>An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The olfactory bulbectomized (OB) rat is a well-accepted animal model of depression. The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ventricular enlargement was also evident in OB animals. These alterations have implications with regard to the face and construct validity of this model.</description><subject>Adult and adolescent clinical studies</subject><subject>Amygdala - physiology</subject><subject>Amygdala - physiopathology</subject><subject>Animal model of depression</subject><subject>Animals</subject><subject>Bioengineering</subject><subject>Biological and medical sciences</subject><subject>Brain - physiology</subject><subject>Brain - physiopathology</subject><subject>Caudate Nucleus - physiology</subject><subject>Caudate Nucleus - physiopathology</subject><subject>Cerebral Cortex - physiology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cerebral Ventricles - physiology</subject><subject>Cerebral Ventricles - physiopathology</subject><subject>Degeneration</subject><subject>Depression</subject><subject>Depression - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Hippocampus - physiology</subject><subject>Hippocampus - physiopathology</subject><subject>Imaging</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>MRI</subject><subject>Olfactory Bulb - physiology</subject><subject>Olfactory bulbectomy</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Reference Values</subject><subject>Ventricular enlargement</subject><issn>0006-8993</issn><issn>1872-6240</issn><issn>0006-8993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotvCI4B8QIgeAmN749inalVRirQSB-BsOfakNUrixU5WWp4eb7Nqb3CyPfrmn5E_Qt4w-MiAyU_fAUBWSmvxAeASuGS6ks_IiqmGV5Kv4TlZPSJn5DznX-UphIaX5IyVCAacr0i7GWkYq33YRzrYuxGn4GjCHEc7OqSh1MJ4R_M0-wONHZ3ukca-s26K6UDbuW-xXIfwBz1NdqJD9NgfQY-7EpNDHF-RF53tM74-nRfk583nH9e31fbbl6_Xm23l1nU9VcoJhrK1Yt1q1SBrUTPOLG-crzXqunHaOiddK7l3ol37plQUc0J5rpiqxQW5XHLvbW92qayeDibaYG43W3OsAWcAXLM9K-z7hd2l-HvGPJkhZId9b0eMczYN57pZQv8NskYqEFoUsF5Al2LOCbvHFRiYozHzYMwcdRgA82DMyNL39jRgbgf0T10nRQV4dwJsdrbvUhET8hNXC8G5KtjVgmH54n3AZLILWBz6kIoi42P4zyZ_Aeelsds</recordid><startdate>20001006</startdate><enddate>20001006</enddate><creator>Wrynn, Aileen S.</creator><creator>Mac Sweeney, Clı́ona P.</creator><creator>Franconi, Florence</creator><creator>Lemaire, Laurent</creator><creator>Pouliquen, Daniel</creator><creator>Herlidou, Sandra</creator><creator>Leonard, Brian E.</creator><creator>Gandon, Jean-Marc</creator><creator>de Certaines, Jacques D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-6725-0803</orcidid><orcidid>https://orcid.org/0000-0002-3765-0889</orcidid><orcidid>https://orcid.org/0000-0002-1308-9345</orcidid></search><sort><creationdate>20001006</creationdate><title>An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression</title><author>Wrynn, Aileen S. ; Mac Sweeney, Clı́ona P. ; Franconi, Florence ; Lemaire, Laurent ; Pouliquen, Daniel ; Herlidou, Sandra ; Leonard, Brian E. ; Gandon, Jean-Marc ; de Certaines, Jacques D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-8c31e6ba34b987e1be9121a27cd59e957c9acc6cb62dc3b4d77c981c38d281853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Amygdala - physiology</topic><topic>Amygdala - physiopathology</topic><topic>Animal model of depression</topic><topic>Animals</topic><topic>Bioengineering</topic><topic>Biological and medical sciences</topic><topic>Brain - physiology</topic><topic>Brain - physiopathology</topic><topic>Caudate Nucleus - physiology</topic><topic>Caudate Nucleus - physiopathology</topic><topic>Cerebral Cortex - physiology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cerebral Ventricles - physiology</topic><topic>Cerebral Ventricles - physiopathology</topic><topic>Degeneration</topic><topic>Depression</topic><topic>Depression - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Hippocampus - physiology</topic><topic>Hippocampus - physiopathology</topic><topic>Imaging</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>MRI</topic><topic>Olfactory Bulb - physiology</topic><topic>Olfactory bulbectomy</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Reference Values</topic><topic>Ventricular enlargement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wrynn, Aileen S.</creatorcontrib><creatorcontrib>Mac Sweeney, Clı́ona P.</creatorcontrib><creatorcontrib>Franconi, Florence</creatorcontrib><creatorcontrib>Lemaire, Laurent</creatorcontrib><creatorcontrib>Pouliquen, Daniel</creatorcontrib><creatorcontrib>Herlidou, Sandra</creatorcontrib><creatorcontrib>Leonard, Brian E.</creatorcontrib><creatorcontrib>Gandon, Jean-Marc</creatorcontrib><creatorcontrib>de Certaines, Jacques D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wrynn, Aileen S.</au><au>Mac Sweeney, Clı́ona P.</au><au>Franconi, Florence</au><au>Lemaire, Laurent</au><au>Pouliquen, Daniel</au><au>Herlidou, Sandra</au><au>Leonard, Brian E.</au><au>Gandon, Jean-Marc</au><au>de Certaines, Jacques D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2000-10-06</date><risdate>2000</risdate><volume>879</volume><issue>1</issue><spage>193</spage><epage>199</epage><pages>193-199</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><eissn>0006-8993</eissn><coden>BRREAP</coden><abstract>The olfactory bulbectomized (OB) rat is a well-accepted animal model of depression. The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ventricular enlargement was also evident in OB animals. These alterations have implications with regard to the face and construct validity of this model.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>11011022</pmid><doi>10.1016/S0006-8993(00)02619-6</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6725-0803</orcidid><orcidid>https://orcid.org/0000-0002-3765-0889</orcidid><orcidid>https://orcid.org/0000-0002-1308-9345</orcidid></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult and adolescent clinical studies Amygdala - physiology Amygdala - physiopathology Animal model of depression Animals Bioengineering Biological and medical sciences Brain - physiology Brain - physiopathology Caudate Nucleus - physiology Caudate Nucleus - physiopathology Cerebral Cortex - physiology Cerebral Cortex - physiopathology Cerebral Ventricles - physiology Cerebral Ventricles - physiopathology Degeneration Depression Depression - physiopathology Disease Models, Animal Hippocampus - physiology Hippocampus - physiopathology Imaging Life Sciences Magnetic Resonance Imaging Medical sciences Mood disorders MRI Olfactory Bulb - physiology Olfactory bulbectomy Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Reference Values Ventricular enlargement |
| title | An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression |
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