An in-vivo magnetic resonance imaging study of the olfactory bulbectomized rat model of depression

The olfactory bulbectomized (OB) rat is a well-accepted animal model of depression. The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ven...

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Veröffentlicht in:Brain research 2000-10, Vol.879 (1), p.193-199
Hauptverfasser: Wrynn, Aileen S., Mac Sweeney, Clı́ona P., Franconi, Florence, Lemaire, Laurent, Pouliquen, Daniel, Herlidou, Sandra, Leonard, Brian E., Gandon, Jean-Marc, de Certaines, Jacques D.
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Sprache:eng
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Zusammenfassung:The olfactory bulbectomized (OB) rat is a well-accepted animal model of depression. The present magnetic resonance imaging (MRI) investigation demonstrates alterations in signal intensities in cortical, hippocampal, caudate and amygdaloid regions in OB animals, but not in sham operated controls. Ventricular enlargement was also evident in OB animals. These alterations have implications with regard to the face and construct validity of this model.
ISSN:0006-8993
1872-6240
0006-8993
DOI:10.1016/S0006-8993(00)02619-6