Rotaxanes of Cyclic Peptides

Rotaxanes of Cyclic Peptides

The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56−63%), despite the disruption of internal amide−amide hydrogen bonding in the macrocycles.

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Veröffentlicht in:Journal of the American Chemical Society 2006-02, Vol.128 (6), p.1784-1785
Hauptverfasser: Aucagne, Vincent, Leigh, David A, Lock, Julia S, Thomson, Andrew R
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Life Sciences
Nuclear Magnetic Resonance, Biomolecular
Organic chemistry
Peptides
Peptides, Cyclic - chemical synthesis
Peptides, Cyclic - chemistry
Preparations and properties
Rotaxanes - chemical synthesis
Rotaxanes - chemistry
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Zusammenfassung:The synthesis of rotaxanes derived from the synthetic peptide macrocycles cyclo(l-ProGly)4 and cyclo(l-ProGly)5 and diammonium threads is described. [2]Rotaxanes are formed in good yields (56−63%), despite the disruption of internal amide−amide hydrogen bonding in the macrocycles.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja057206q