Cushing Syndrome Is Associated With Subclinical LV Dysfunction and Increased Epicardial Adipose Tissue
Multivariate analysis (including age, sex, body mass index, blood pressure, fasting plasma glucose, and EAT) revealed that EAT volume was independently associated with LVMi (β = 0.40; p = 0.008) and LVMi/EDVi (β = 0.41; p = 0.011). [...]we demonstrated a unique pattern of ectopic fat deposition in p...
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| creator | Maurice, Flavia Gaborit, Bénédicte Vincentelli, Clara Abdesselam, Ines Bernard, Monique Graillon, Thomas Kober, Frank Brue, Thierry Castinetti, Frédéric Dutour, Anne |
| description | Multivariate analysis (including age, sex, body mass index, blood pressure, fasting plasma glucose, and EAT) revealed that EAT volume was independently associated with LVMi (β = 0.40; p = 0.008) and LVMi/EDVi (β = 0.41; p = 0.011). [...]we demonstrated a unique pattern of ectopic fat deposition in patients with active ACTH-dependent CS, with a relatively high epicardial fat accumulation. Active Group (n = 19) Remission Group (n = 19) Control Group (n = 19) p Value 2-Group 3-Group Duration of uncontrolled CS, months 25.6 ± 15.7 32.6 ± 31.4 — NS — Clinical parameters BMI, kg/m2 26.9 ± 3.5 26.3 ± 4.8 21.9 ± 2.9 |
| doi_str_mv | 10.1016/j.jacc.2018.07.096 |
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[...]we demonstrated a unique pattern of ectopic fat deposition in patients with active ACTH-dependent CS, with a relatively high epicardial fat accumulation. Active Group (n = 19) Remission Group (n = 19) Control Group (n = 19) p Value 2-Group 3-Group Duration of uncontrolled CS, months 25.6 ± 15.7 32.6 ± 31.4 — NS — Clinical parameters BMI, kg/m2 26.9 ± 3.5 26.3 ± 4.8 21.9 ± 2.9 <0.05∗† <0.001 Waist/hip ratio 0.97 ± 0.07 0.94 (0.84–0.98) 0.88 (0.81–0.93) <0.05∗ 0.014 Systolic BP, mm Hg 130 ± 22 112 ± 13 113 (105–132) <0.05‡ 0.018 Diastolic BP, mm Hg 80 ± 11 70 ± 11 73 ± 11 <0.05∗‡ 0.017 Metabolic parameters Fasting plasma glucose, mmol/l 5.67 ± 1.24 4.42 ± 0.69 4.79 ± 0.39 <0.05∗‡ <0.001 HbA1c, % 6.71 ± 1.65 5.66 ± 0.49 — <0.05‡ — Serum triglyceride levels, mmol/l 1.36 (0.94–1.94) 0.95 (0.72–1.57) 0.87 ± 0.22 <0.05∗ 0.024 Total blood cholesterol levels, mmol/l 5.62 ± 1.21 5.39 ± 0.90 5.42 ± 1.02 NS NS LDL cholesterol levels, mmol/l 3.35 ± 1.01 3.06 ± 0.58 3.13 ± 0.79 NS NS HDL cholesterol levels, mmol/l 1.48 (1.19–2.04) 1.74 ± 0.53 1.89 ± 0.48 NS NS Inflammation biomarkers Plasma fibrinogen levels, g/l 3.43 ± 0.73 3.52 ± 0.87 — NS — High-sensitivity C-reactive protein, mg/l 1.4 (0.5–2.9) 1.6 (0.8–5.2) — NS — Serum ferritin levels, μg/l 135 (44–249) 78 (35–114) — NS — CMR body composition VAT/sSCAT 0.98 (0.78–2.14) 0.63 (0.44–1.06) 0.84 ± 0.36 <0.05‡ 0.017 CMR epicardial adipose tissue (EAT) assessment EAT volume, ml 93.5 ± 26.6 68.2 ± 22.1 55.2 ± 15.9 <0.05∗†‡ <0.001 LV morphology and function E/A ratio 1.34 ± 0.30 1.59 ± 0.37 1.66 ± 0.33 <0.05∗ 0.031 LV mass index, g/m2 55.3 ± 11.3 40.9 (36.0–45.6) 43.2 ± 10.2 <0.05∗‡ <0.001 LV mass index to end-diastolic volume, g/ml 1.10 ± 0.30 0.75 (0.66–0.99) 0.68 ± 0.11 <0.05∗†‡ <0.001 Table 1 Characteristics of Study Population]]></description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2018.07.096</identifier><identifier>PMID: 30360834</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose tissue ; Adipose Tissue - diagnostic imaging ; Adipose Tissue - physiopathology ; Adrenocorticotropic hormone ; Adult ; Body fat ; Body mass index ; Cardiology ; Cardiovascular disease ; Cholesterol ; Cushing Syndrome - diagnostic imaging ; Cushing Syndrome - epidemiology ; Cushing Syndrome - physiopathology ; Female ; Humans ; Hypertension ; Life Sciences ; Male ; Multivariate analysis ; Nervous system diseases ; Pericardium - diagnostic imaging ; Pericardium - physiopathology ; Pituitary ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - epidemiology ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Journal of the American College of Cardiology, 2018-10, Vol.72 (18), p.2276-2277</ispartof><rights>2018 American College of Cardiology Foundation</rights><rights>2018. American College of Cardiology Foundation</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-c28c4d174447f0ab79e9dc0e5907a06a8abbee5a277af423d4547f3dbbb3738d3</citedby><cites>FETCH-LOGICAL-c462t-c28c4d174447f0ab79e9dc0e5907a06a8abbee5a277af423d4547f3dbbb3738d3</cites><orcidid>0000-0002-7869-3615 ; 0000-0002-1808-8800 ; 0000-0001-5627-8181 ; 0000-0001-8482-6691</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0735109718382317$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30360834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-02068079$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Maurice, Flavia</creatorcontrib><creatorcontrib>Gaborit, Bénédicte</creatorcontrib><creatorcontrib>Vincentelli, Clara</creatorcontrib><creatorcontrib>Abdesselam, Ines</creatorcontrib><creatorcontrib>Bernard, Monique</creatorcontrib><creatorcontrib>Graillon, Thomas</creatorcontrib><creatorcontrib>Kober, Frank</creatorcontrib><creatorcontrib>Brue, Thierry</creatorcontrib><creatorcontrib>Castinetti, Frédéric</creatorcontrib><creatorcontrib>Dutour, Anne</creatorcontrib><title>Cushing Syndrome Is Associated With Subclinical LV Dysfunction and Increased Epicardial Adipose Tissue</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description><![CDATA[Multivariate analysis (including age, sex, body mass index, blood pressure, fasting plasma glucose, and EAT) revealed that EAT volume was independently associated with LVMi (β = 0.40; p = 0.008) and LVMi/EDVi (β = 0.41; p = 0.011). [...]we demonstrated a unique pattern of ectopic fat deposition in patients with active ACTH-dependent CS, with a relatively high epicardial fat accumulation. Active Group (n = 19) Remission Group (n = 19) Control Group (n = 19) p Value 2-Group 3-Group Duration of uncontrolled CS, months 25.6 ± 15.7 32.6 ± 31.4 — NS — Clinical parameters BMI, kg/m2 26.9 ± 3.5 26.3 ± 4.8 21.9 ± 2.9 <0.05∗† <0.001 Waist/hip ratio 0.97 ± 0.07 0.94 (0.84–0.98) 0.88 (0.81–0.93) <0.05∗ 0.014 Systolic BP, mm Hg 130 ± 22 112 ± 13 113 (105–132) <0.05‡ 0.018 Diastolic BP, mm Hg 80 ± 11 70 ± 11 73 ± 11 <0.05∗‡ 0.017 Metabolic parameters Fasting plasma glucose, mmol/l 5.67 ± 1.24 4.42 ± 0.69 4.79 ± 0.39 <0.05∗‡ <0.001 HbA1c, % 6.71 ± 1.65 5.66 ± 0.49 — <0.05‡ — Serum triglyceride levels, mmol/l 1.36 (0.94–1.94) 0.95 (0.72–1.57) 0.87 ± 0.22 <0.05∗ 0.024 Total blood cholesterol levels, mmol/l 5.62 ± 1.21 5.39 ± 0.90 5.42 ± 1.02 NS NS LDL cholesterol levels, mmol/l 3.35 ± 1.01 3.06 ± 0.58 3.13 ± 0.79 NS NS HDL cholesterol levels, mmol/l 1.48 (1.19–2.04) 1.74 ± 0.53 1.89 ± 0.48 NS NS Inflammation biomarkers Plasma fibrinogen levels, g/l 3.43 ± 0.73 3.52 ± 0.87 — NS — High-sensitivity C-reactive protein, mg/l 1.4 (0.5–2.9) 1.6 (0.8–5.2) — NS — Serum ferritin levels, μg/l 135 (44–249) 78 (35–114) — NS — CMR body composition VAT/sSCAT 0.98 (0.78–2.14) 0.63 (0.44–1.06) 0.84 ± 0.36 <0.05‡ 0.017 CMR epicardial adipose tissue (EAT) assessment EAT volume, ml 93.5 ± 26.6 68.2 ± 22.1 55.2 ± 15.9 <0.05∗†‡ <0.001 LV morphology and function E/A ratio 1.34 ± 0.30 1.59 ± 0.37 1.66 ± 0.33 <0.05∗ 0.031 LV mass index, g/m2 55.3 ± 11.3 40.9 (36.0–45.6) 43.2 ± 10.2 <0.05∗‡ <0.001 LV mass index to end-diastolic volume, g/ml 1.10 ± 0.30 0.75 (0.66–0.99) 0.68 ± 0.11 <0.05∗†‡ <0.001 Table 1 Characteristics of Study Population]]></description><subject>Adipose tissue</subject><subject>Adipose Tissue - diagnostic imaging</subject><subject>Adipose Tissue - physiopathology</subject><subject>Adrenocorticotropic hormone</subject><subject>Adult</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Cushing Syndrome - diagnostic imaging</subject><subject>Cushing Syndrome - epidemiology</subject><subject>Cushing Syndrome - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Multivariate analysis</subject><subject>Nervous system diseases</subject><subject>Pericardium - diagnostic imaging</subject><subject>Pericardium - physiopathology</subject><subject>Pituitary</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - epidemiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90cFu1DAQBmALgehSeAEOyBKXckgYx0mcSFxWS0tXWolDCxwtx56wjrL2YieV9u1xtG0PHLjYkvXNyDM_Ie8Z5AxY_XnIB6V1XgBrchA5tPULsmJV1WS8asVLsgLBq4xBKy7ImxgHAKgb1r4mFxx4DQ0vV6TfzHFv3W96d3Im-APSbaTrGL22akJDf9lpT-_mTo_WWa1GuvtJv55iPzs9We-ocoZunQ6oYtLXx2SCscmtjT36iPTexjjjW_KqV2PEd4_3Jflxc32_uc12379tN-tdpsu6mDJdNLo0TJRlKXpQnWixNRqwakEoqFWjug6xUoUQqi8LbsoqQW66ruOCN4Zfkk_nvns1ymOwBxVO0isrb9c7ubxBkXYAon1gyV6d7TH4PzPGSR5s1DiOyqGfoyxYUbcMoGkS_fgPHfwcXJpkUWVKIx1JFWelg48xYP_8AwZySUwOcklMLolJEDIlloo-PLaeuwOa55KniBL4cgaY9vZgMcioLTqNxgbUkzTe_q__X87FpfU</recordid><startdate>20181030</startdate><enddate>20181030</enddate><creator>Maurice, Flavia</creator><creator>Gaborit, Bénédicte</creator><creator>Vincentelli, Clara</creator><creator>Abdesselam, Ines</creator><creator>Bernard, Monique</creator><creator>Graillon, Thomas</creator><creator>Kober, Frank</creator><creator>Brue, Thierry</creator><creator>Castinetti, Frédéric</creator><creator>Dutour, Anne</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0002-7869-3615</orcidid><orcidid>https://orcid.org/0000-0002-1808-8800</orcidid><orcidid>https://orcid.org/0000-0001-5627-8181</orcidid><orcidid>https://orcid.org/0000-0001-8482-6691</orcidid></search><sort><creationdate>20181030</creationdate><title>Cushing Syndrome Is Associated With Subclinical LV Dysfunction and Increased Epicardial Adipose Tissue</title><author>Maurice, Flavia ; Gaborit, Bénédicte ; Vincentelli, Clara ; Abdesselam, Ines ; Bernard, Monique ; Graillon, Thomas ; Kober, Frank ; Brue, Thierry ; Castinetti, Frédéric ; Dutour, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-c28c4d174447f0ab79e9dc0e5907a06a8abbee5a277af423d4547f3dbbb3738d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - diagnostic imaging</topic><topic>Adipose Tissue - physiopathology</topic><topic>Adrenocorticotropic hormone</topic><topic>Adult</topic><topic>Body fat</topic><topic>Body mass index</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Cushing Syndrome - diagnostic imaging</topic><topic>Cushing Syndrome - epidemiology</topic><topic>Cushing Syndrome - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Multivariate analysis</topic><topic>Nervous system diseases</topic><topic>Pericardium - diagnostic imaging</topic><topic>Pericardium - physiopathology</topic><topic>Pituitary</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - epidemiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maurice, Flavia</creatorcontrib><creatorcontrib>Gaborit, Bénédicte</creatorcontrib><creatorcontrib>Vincentelli, Clara</creatorcontrib><creatorcontrib>Abdesselam, Ines</creatorcontrib><creatorcontrib>Bernard, Monique</creatorcontrib><creatorcontrib>Graillon, Thomas</creatorcontrib><creatorcontrib>Kober, Frank</creatorcontrib><creatorcontrib>Brue, Thierry</creatorcontrib><creatorcontrib>Castinetti, Frédéric</creatorcontrib><creatorcontrib>Dutour, Anne</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maurice, Flavia</au><au>Gaborit, Bénédicte</au><au>Vincentelli, Clara</au><au>Abdesselam, Ines</au><au>Bernard, Monique</au><au>Graillon, Thomas</au><au>Kober, Frank</au><au>Brue, Thierry</au><au>Castinetti, Frédéric</au><au>Dutour, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cushing Syndrome Is Associated With Subclinical LV Dysfunction and Increased Epicardial Adipose Tissue</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2018-10-30</date><risdate>2018</risdate><volume>72</volume><issue>18</issue><spage>2276</spage><epage>2277</epage><pages>2276-2277</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract><![CDATA[Multivariate analysis (including age, sex, body mass index, blood pressure, fasting plasma glucose, and EAT) revealed that EAT volume was independently associated with LVMi (β = 0.40; p = 0.008) and LVMi/EDVi (β = 0.41; p = 0.011). [...]we demonstrated a unique pattern of ectopic fat deposition in patients with active ACTH-dependent CS, with a relatively high epicardial fat accumulation. Active Group (n = 19) Remission Group (n = 19) Control Group (n = 19) p Value 2-Group 3-Group Duration of uncontrolled CS, months 25.6 ± 15.7 32.6 ± 31.4 — NS — Clinical parameters BMI, kg/m2 26.9 ± 3.5 26.3 ± 4.8 21.9 ± 2.9 <0.05∗† <0.001 Waist/hip ratio 0.97 ± 0.07 0.94 (0.84–0.98) 0.88 (0.81–0.93) <0.05∗ 0.014 Systolic BP, mm Hg 130 ± 22 112 ± 13 113 (105–132) <0.05‡ 0.018 Diastolic BP, mm Hg 80 ± 11 70 ± 11 73 ± 11 <0.05∗‡ 0.017 Metabolic parameters Fasting plasma glucose, mmol/l 5.67 ± 1.24 4.42 ± 0.69 4.79 ± 0.39 <0.05∗‡ <0.001 HbA1c, % 6.71 ± 1.65 5.66 ± 0.49 — <0.05‡ — Serum triglyceride levels, mmol/l 1.36 (0.94–1.94) 0.95 (0.72–1.57) 0.87 ± 0.22 <0.05∗ 0.024 Total blood cholesterol levels, mmol/l 5.62 ± 1.21 5.39 ± 0.90 5.42 ± 1.02 NS NS LDL cholesterol levels, mmol/l 3.35 ± 1.01 3.06 ± 0.58 3.13 ± 0.79 NS NS HDL cholesterol levels, mmol/l 1.48 (1.19–2.04) 1.74 ± 0.53 1.89 ± 0.48 NS NS Inflammation biomarkers Plasma fibrinogen levels, g/l 3.43 ± 0.73 3.52 ± 0.87 — NS — High-sensitivity C-reactive protein, mg/l 1.4 (0.5–2.9) 1.6 (0.8–5.2) — NS — Serum ferritin levels, μg/l 135 (44–249) 78 (35–114) — NS — CMR body composition VAT/sSCAT 0.98 (0.78–2.14) 0.63 (0.44–1.06) 0.84 ± 0.36 <0.05‡ 0.017 CMR epicardial adipose tissue (EAT) assessment EAT volume, ml 93.5 ± 26.6 68.2 ± 22.1 55.2 ± 15.9 <0.05∗†‡ <0.001 LV morphology and function E/A ratio 1.34 ± 0.30 1.59 ± 0.37 1.66 ± 0.33 <0.05∗ 0.031 LV mass index, g/m2 55.3 ± 11.3 40.9 (36.0–45.6) 43.2 ± 10.2 <0.05∗‡ <0.001 LV mass index to end-diastolic volume, g/ml 1.10 ± 0.30 0.75 (0.66–0.99) 0.68 ± 0.11 <0.05∗†‡ <0.001 Table 1 Characteristics of Study Population]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30360834</pmid><doi>10.1016/j.jacc.2018.07.096</doi><tpages>2</tpages><orcidid>https://orcid.org/0000-0002-7869-3615</orcidid><orcidid>https://orcid.org/0000-0002-1808-8800</orcidid><orcidid>https://orcid.org/0000-0001-5627-8181</orcidid><orcidid>https://orcid.org/0000-0001-8482-6691</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose tissue Adipose Tissue - diagnostic imaging Adipose Tissue - physiopathology Adrenocorticotropic hormone Adult Body fat Body mass index Cardiology Cardiovascular disease Cholesterol Cushing Syndrome - diagnostic imaging Cushing Syndrome - epidemiology Cushing Syndrome - physiopathology Female Humans Hypertension Life Sciences Male Multivariate analysis Nervous system diseases Pericardium - diagnostic imaging Pericardium - physiopathology Pituitary Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Left - physiopathology |
| title | Cushing Syndrome Is Associated With Subclinical LV Dysfunction and Increased Epicardial Adipose Tissue |
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