Cushing Syndrome Is Associated With Subclinical LV Dysfunction and Increased Epicardial Adipose Tissue

Multivariate analysis (including age, sex, body mass index, blood pressure, fasting plasma glucose, and EAT) revealed that EAT volume was independently associated with LVMi (β = 0.40; p = 0.008) and LVMi/EDVi (β = 0.41; p = 0.011). [...]we demonstrated a unique pattern of ectopic fat deposition in patients with active ACTH-dependent CS, with a relatively high epicardial fat accumulation. Active Group (n = 19) Remission Group (n = 19) Control Group (n = 19) p Value 2-Group 3-Group Duration of uncontrolled CS, months 25.6 ± 15.7 32.6 ± 31.4 — NS — Clinical parameters BMI, kg/m2 26.9 ± 3.5 26.3 ± 4.8 21.9 ± 2.9