Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD

The frequency of COPD exacerbations during treatment with a triple inhaler — delivering a long-acting beta-agonist (LABA), a long-acting muscarinic antagonist (LAMA), and an inhaled glucocorticoid — was compared with that with a LABA–LAMA or LABA–inhaled glucocorticoid.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-05, Vol.378 (18), p.1671-1680
Hauptverfasser:	Lipson, David A, Barnhart, Frank, Brealey, Noushin, Brooks, Jean, Criner, Gerard J, Day, Nicola C, Dransfield, Mark T, Halpin, David M.G, Han, MeiLan K, Jones, C. Elaine, Kilbride, Sally, Lange, Peter, Lomas, David A, Martinez, Fernando J, Singh, Dave, Tabberer, Maggie, Wise, Robert A, Pascoe, Steven J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors (muscarinic) Administration, Inhalation Adrenergic beta-Agonists - administration & dosage Adrenergic beta-Agonists - adverse effects Adult Aged Androstadienes - administration & dosage Benzyl Alcohols - administration & dosage Bronchodilator Agents - administration & dosage Bronchodilator Agents - adverse effects Chlorobenzenes - administration & dosage Chronic obstructive pulmonary disease Critical care Double-Blind Method Drug Administration Schedule Drug Combinations Drug dosages Dyspnea - drug therapy Dyspnea - etiology Female Fluticasone Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Hospitalization - statistics & numerical data Hospitals Human health and pathology Humans Inhalers Intention to Treat Analysis Life Sciences Lung diseases Male Medicine Middle Aged Muscarinic Antagonists - administration & dosage Muscarinic Antagonists - adverse effects Obstructive lung disease Patients Pneumonia Population Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonology and respiratory tract Quality of Life Quinuclidines - administration & dosage
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Beschreibung
Zusammenfassung:	The frequency of COPD exacerbations during treatment with a triple inhaler — delivering a long-acting beta-agonist (LABA), a long-acting muscarinic antagonist (LAMA), and an inhaled glucocorticoid — was compared with that with a LABA–LAMA or LABA–inhaled glucocorticoid.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1713901