An efficient and simple one-pot synthesis of 2-perfluoroalkylated benzo[1,3]dioxole derivatives via double–Michael reaction of fluorinated alkynes
[Display omitted] •Efficient regioselective synthesis of 2-fluoroalkylated-benzo[d][1,3]dioxoles. Synthesis of fluoroalkylated benzoxazolines and benzothiazoline. Double-Michael reaction. An efficient, mild and very easy method for the synthesis of 2-fluoroalkylated 1,3-benzodioxole derivatives was...
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Veröffentlicht in: | Journal of fluorine chemistry 2018-08, Vol.212, p.45-50 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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•Efficient regioselective synthesis of 2-fluoroalkylated-benzo[d][1,3]dioxoles. Synthesis of fluoroalkylated benzoxazolines and benzothiazoline. Double-Michael reaction.
An efficient, mild and very easy method for the synthesis of 2-fluoroalkylated 1,3-benzodioxole derivatives was developed through a double Michael-addition reaction on ethyl 4,4,4-trifluorobut-2-ynoate with corresponding catechols. The procedure does not require the use of expensive supplementary additives for the preparation of 2-fluoroalkylated benzo ketals. |
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ISSN: | 0022-1139 1873-3328 |
DOI: | 10.1016/j.jfluchem.2018.05.005 |