MRI probes based on C6-peracetate β-cyclodextrins: Synthesis, gadolinium complexation and in vivo relaxivity studies

The initial synthesis of two β-cyclodextrins derivatives bearing seven carboxylate ligands was optimized in order to improve the production of contrast agents. A speciation study using potentiometric analysis was performed on the gadolinium(III) complex. For the first time, in vivo myocardic activity was evaluated on mice. This study highlighted the best efficiency for the cyclodextrin derivative having free hydroxyl groups and validated the biomedical potential of the flexible cyclodextrin scaffold as a cardiac MRI probe. [Display omitted] The initial synthesis of two β-cyclodextrin derivatives bearing seven carboxylate ligands was optimized in order to improve the production of contrast agents. A speciation study using potentiometric analysis was performed on a gadolinium(III) complex. The in vivo myocardic activity was evaluated on mice. This study highlights the best efficiency for the cyclodextrin derivative having free hydroxyl groups and validated the biomedical potential of the flexible cyclodextrin scaffold as a cardiac MRI probe.