Determinants of Successful Methicillin-Resistant Staphylococcus aureus Decolonization

According to our univariate analysis, cases were more likely to live without assistance, having only the nose or groin colonized (and not both), and a shorter length of hospital stay after treatment was initiated. No association was found between MRSA decolonization success and the following variables: gender, body-mass index, other comorbidities, McCabe score, skin damage, antibiotic treatment, MRSA strain type, MRSA quantity at baseline, newly identified MRSA status, polyhexanide treatment, and location of treatment administration.TABLE 1 Patients and Treatment Characteristics, Univariate and Multivariate Logistic Regression to Predict Successful MRSA Decolonization Univariate Logistic Regression Multivariate Logistic Regression Variables MRSA-Negative Cases(N=46) MRSA-Positive Controls (N=89) P Value OR 95% CI P Value aOR 95% CI P Value Patient characteristics Gender, No. (%) .824 Male 27 (58.7) 54 (60.7) Female 19 (41.3) 35 (39.3) Age, mean (±SD) y (ULR per 1-year increment) 61.9 (±16.07) 66.8 (±14.86) .078 0.98 0.96–1.00 .079 BMI (kg/m2), No. (%) .883 30 16 (34.8) 28 (31.8) Presence of at least 1 comorbidity, No. (%) 34 (73.9) 68 (76.4) .750 Absence of comorbidities, No. (%) Cardiovascular disease 23 (50.0) 41 (46.1) .664 COPD 41 (89.1) 70 (78.7) .131 2.23 0.77–6.41 .119 Chronic renal failure 38 (82.6) 72 (80.9) .808 Chronic liver disease 40 (87.0) 81 (91.0) .464 Malignancy 42 (91.3) 71 (79.8) .086 2.66 0.84–8.40 .073 Diabetes mellitus 38 (82.6) 77 (86.5) .545 Immunodeficiency 34 (73.9) 64 (71.9) .805 Degree of dependence, No. (%) .006 .005 Dependent or semi-dependent 11 (23.9) 43 (48.3) 1.00 … According to our multivariate analysis (Table 1), 2 independent factors were associated with successful MRSA decolonization: independent status (adjusted odds ratio [aOR], 2.83; 95% CI, 1.26–6.34; P=.011) and only 1 MRSA-colonized body site at baseline (aOR, 2.16; 95% CI, 1.03–4.56; P=.042). A limitation of this study was the reduced number of eligible patients for the RCT, excluding the sickest patients and those receiving systemic antibiotic treatment for MRSA infection. [...]this study population may not be representative of all MRSA patients.