Performances of fourth generation HIV antigen/antibody assays on filter paper for detection of early HIV infections

Highlights • Rapid diagnosis of HIV acute infections plays important role in preventing transmission. • Good performance of 4th generation IAs on DSS during the early phases of HIV infection. • 4th generation IAs on DSS are more sensitive than RDTs in HIV infection early phases. • DSS may play a sig...

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Veröffentlicht in:	Journal of clinical virology 2015-01, Vol.62, p.92-97
Hauptverfasser:	Kania, Dramane, Truong, Tam Nguyen, Montoya, Ana, Nagot, Nicolas, Van de Perre, Philippe, Tuaillon, Edouard
Format:	Artikel
Sprache:	eng
Schlagworte:	4th generation immunoassay Acute infection Adult Allergy and Immunology CD4 Lymphocyte Count Dried blood spot Female HIV Antibodies - immunology HIV Antigens - immunology HIV Core Protein p24 - immunology HIV Infections - diagnosis HIV Infections - immunology HIV Infections - virology HIV-1 HIV-1 - immunology HIV-2 - immunology Human health and pathology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunoassay - methods Immunoassay - standards Infectious Disease Life Sciences Male Mass Screening Middle Aged p24 antigen Point-of-care Point-of-Care Systems - standards Reagent Kits, Diagnostic - standards Reproducibility of Results Sensitivity and Specificity Viral Load
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Beschreibung
Zusammenfassung:	Highlights • Rapid diagnosis of HIV acute infections plays important role in preventing transmission. • Good performance of 4th generation IAs on DSS during the early phases of HIV infection. • 4th generation IAs on DSS are more sensitive than RDTs in HIV infection early phases. • DSS may play a significant role in early HIV diagnosing in hard-to-reach/remote areas.
ISSN:	1386-6532 1873-5967
DOI:	10.1016/j.jcv.2014.11.005