Temperature-Responsive Polymer Brushes Switching from Bactericidal to Cell-Repellent

The composition of temperature‐responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature of ∼35 °C. The chains are grafted by antibacterial magainin I peptide, whose activity is tested at different temperatures against various bacteria. The...

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Veröffentlicht in:	Advanced materials (Weinheim) 2010-11, Vol.22 (44), p.5024-5028
Hauptverfasser:	Laloyaux, Xavier, Fautré, Emilie, Blin, Thomas, Purohit, Viswas, Leprince, Jérôme, Jouenne, Thierry, Jonas, Alain M., Glinel, Karine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial Surfaces Antimicrobial Cationic Peptides Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Bacteria Bacteria - drug effects Cell Behavior Cellular Biology Chemical Sciences Coated Materials, Biocompatible Coated Materials, Biocompatible - chemistry Coated Materials, Biocompatible - pharmacology Ethylene Glycols Ethylene Glycols - chemistry Ethylene Glycols - pharmacology Functional Coatings Life Sciences Medicinal Chemistry Methacrylates Methacrylates - chemistry Methacrylates - pharmacology Neurobiology Neurons and Cognition Pharmaceutical sciences Pharmacology Stimuli-Responsive Materials Surface Modification Surface Properties Temperature Thin Films Transition Temperature Xenopus Xenopus - metabolism Xenopus Proteins Xenopus Proteins - chemistry Xenopus Proteins - pharmacology
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Zusammenfassung:	The composition of temperature‐responsive copolymer brushes based on oligo(ethylene glycol) methacrylates is tuned to obtain a collapse temperature of ∼35 °C. The chains are grafted by antibacterial magainin I peptide, whose activity is tested at different temperatures against various bacteria. The brushes switch from bactericidal to cell‐repellent below and slightly above 35 °C, respectively, due to the progressive vertical collapse of the brush.
ISSN:	0935-9648 1521-4095
DOI:	10.1002/adma.201002538