A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis

In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone. Bezafibrate was associated with increases in creatinine and myalgias.

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Veröffentlicht in:	The New England journal of medicine 2018-06, Vol.378 (23), p.2171-2181
Hauptverfasser:	Corpechot, Christophe, Chazouillères, Olivier, Rousseau, Alexandra, Le Gruyer, Antonia, Habersetzer, François, Mathurin, Philippe, Goria, Odile, Potier, Pascal, Minello, Anne, Silvain, Christine, Abergel, Armand, Debette-Gratien, Maryline, Larrey, Dominique, Roux, Olivier, Bronowicki, Jean-Pierre, Boursier, Jérôme, de Ledinghen, Victor, Heurgue-Berlot, Alexandra, Nguyen-Khac, Eric, Zoulim, Fabien, Ollivier-Hourmand, Isabelle, Zarski, Jean-Pierre, Nkontchou, Gisèle, Lemoinne, Sara, Humbert, Lydie, Rainteau, Dominique, Lefèvre, Guillaume, de Chaisemartin, Luc, Chollet-Martin, Sylvie, Gaouar, Farid, Admane, Farid-Hakeem, Simon, Tabassome, Poupon, Raoul
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adult Alkaline phosphatase Bezafibrate Bezafibrate - adverse effects Bezafibrate - therapeutic use Bile Bile Acids and Salts - blood Bilirubin Biochemistry Cholangitis Cholangitis - drug therapy Cholangitis - etiology Cholesterol Creatinine Double-Blind Method Fatigue Female Fibrosis Gallbladder diseases Gastroenterology Hepatitis Hepatology Hospitals Human health and pathology Humans Hypertension Hypolipidemic Agents - adverse effects Hypolipidemic Agents - therapeutic use Laboratories Life Sciences Liver Liver Cirrhosis, Biliary - complications Liver Cirrhosis, Biliary - drug therapy Liver diseases Male Middle Aged Myalgia Patients Peroxisome proliferator-activated receptors Phosphatase Placebos - therapeutic use Prothrombin Pruritus Quality of life Treatment Failure Tumor necrosis factor-TNF Ursodeoxycholic acid Ursodeoxycholic Acid - therapeutic use
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Beschreibung
Zusammenfassung:	In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone. Bezafibrate was associated with increases in creatinine and myalgias.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1714519