Crystal Structures and Phase Relationships of 2 Polymorphs of 1,4-Diazabicyclo[3.2.2]nonane-4-Carboxylic Acid 4-Bromophenyl Ester Fumarate, A Selective α-7 Nicotinic Receptor Partial Agonist

Two polymorphs of the 1:1 fumarate salt of 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester, developed for the treatment of cognitive symptoms of schizophrenia and Alzheimer disease, have been characterized. The 2 crystal structures have been solved, and their phase relationships...

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Veröffentlicht in:Journal of pharmaceutical sciences 2016-01, Vol.105 (1), p.64-70
Hauptverfasser: Robert, Benoît, Perrin, Marc-Antoine, Barrio, Maria, Tamarit, Josep-Lluis, Coquerel, Gérard, Ceolin, René, Rietveld, Ivo B.
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Sprache:eng
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