Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment
Purpose Dosimetry for melanoma‐targeted radionuclide therapy (TRT) with [131I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT‐CT imaging and ex vi...
Gespeichert in:
| Veröffentlicht in: | Medical physics (Lancaster) 2018-11, Vol.45 (11), p.5251-5262 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5262 |
|---|---|
| container_issue | 11 |
| container_start_page | 5251 |
| container_title | Medical physics (Lancaster) |
| container_volume | 45 |
| creator | Jouberton, Elodie Perrot, Yann Dirat, Béatrice Billoux, Tommy Auzeloux, Philippe Cachin, Florent Chezal, Jean‐Michel Filaire, Marc Labarre, Pierre Miot‐Noirault, Elisabeth Millardet, Corinne Valla, Clémence Vidal, Aurélien Degoul, Françoise Maigne, Lydia |
| description | Purpose
Dosimetry for melanoma‐targeted radionuclide therapy (TRT) with [131I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT‐CT imaging and ex vivo measurements.
Material and Methods
Ex vivo biodistribution (i.v. injection: 370 kBq/kg, n = 2 per point) is performed on blood, eyes, brain, lung, liver, kidneys, heart, stomach, and spleen. Dosimetry calculations follow the MIRD formalism: S values are calculated from CT images using the GATE Monte Carlo platform and activity distributions are obtained from SPECT‐CT imaging (i.v. injection: 37 MBq/kg n = 3 per point). A specific study is presented to assess dose to human retina.
Results
Time‐integrated activities based on SPECT‐CT are in accordance with ex vivo measurements except for spleen. Doses to liver and eyes are the most significant, with respectively, 6.38 ± 0.50 Gy/GBq (evaluated through SPECT‐CT imaging) and 45.8 ± 7.9 Gy/GBq (evaluated through ex vivo measurements). Characterization of ocular [131I]ICF01012 biodistribution in rabbits and quantification of melanin allowed to assess a dose of 3.07 ± 0.70 Gy/GBq to human retina.
Conclusion
This study sustains [131I]ICF01012 as a good candidate for melanoma TRT and open perspectives for personalized dosimetry calculation during phase I clinical transfer. |
| doi_str_mv | 10.1002/mp.13165 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_01925049v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2099433856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3555-7b830b639fce6f4dc9bff6ace56a0d85ed3e0fc80bf73541f1528ec27de8179b3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7rgK_gLJUQ-9Vjqd_vA2DO7uwIgiehIJ6aTiRDqdNkkrw_55e-11PXkqKJ56qKqXkOcMLhhA-dpPF4yzWjwgm7JqeFGV0D0kG4CuKsoKxBl5ktJ3AKi5gMfkjANrurJuNuTmozJOZRdGakJyHnM80WDpl8W3_7rfXQIDVlI30qj63uX0hm6naXB6ncmBZhW_YUazAGZpzXpwBmk-YlTTidoQ6XH2aqQeBzUGr2iOqLLHMT8lj6waEj67q-fk8-XbT7vr4vD-ar_bHgrNhRBF07cc-pp3VmNtK6O73tpaaRS1AtMKNBzB6hZ623BRMctE2aIuG4PtcmbPz8mr1XtUg5yi8yqeZFBOXm8P8rYHrCsFVN1PtrAvV3aK4ceMKUvvksZh2R3DnOTy2K7ivBX1P1THkFJEe-9mIG9jkX6Sf2JZ0Bd31rn3aO7BvzksQLECv9yAp_-K5LsPq_A3FPSVqQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2099433856</pqid></control><display><type>article</type><title>Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment</title><source>MEDLINE</source><source>Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Jouberton, Elodie ; Perrot, Yann ; Dirat, Béatrice ; Billoux, Tommy ; Auzeloux, Philippe ; Cachin, Florent ; Chezal, Jean‐Michel ; Filaire, Marc ; Labarre, Pierre ; Miot‐Noirault, Elisabeth ; Millardet, Corinne ; Valla, Clémence ; Vidal, Aurélien ; Degoul, Françoise ; Maigne, Lydia</creator><creatorcontrib>Jouberton, Elodie ; Perrot, Yann ; Dirat, Béatrice ; Billoux, Tommy ; Auzeloux, Philippe ; Cachin, Florent ; Chezal, Jean‐Michel ; Filaire, Marc ; Labarre, Pierre ; Miot‐Noirault, Elisabeth ; Millardet, Corinne ; Valla, Clémence ; Vidal, Aurélien ; Degoul, Françoise ; Maigne, Lydia</creatorcontrib><description>Purpose
Dosimetry for melanoma‐targeted radionuclide therapy (TRT) with [131I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT‐CT imaging and ex vivo measurements.
Material and Methods
Ex vivo biodistribution (i.v. injection: 370 kBq/kg, n = 2 per point) is performed on blood, eyes, brain, lung, liver, kidneys, heart, stomach, and spleen. Dosimetry calculations follow the MIRD formalism: S values are calculated from CT images using the GATE Monte Carlo platform and activity distributions are obtained from SPECT‐CT imaging (i.v. injection: 37 MBq/kg n = 3 per point). A specific study is presented to assess dose to human retina.
Results
Time‐integrated activities based on SPECT‐CT are in accordance with ex vivo measurements except for spleen. Doses to liver and eyes are the most significant, with respectively, 6.38 ± 0.50 Gy/GBq (evaluated through SPECT‐CT imaging) and 45.8 ± 7.9 Gy/GBq (evaluated through ex vivo measurements). Characterization of ocular [131I]ICF01012 biodistribution in rabbits and quantification of melanin allowed to assess a dose of 3.07 ± 0.70 Gy/GBq to human retina.
Conclusion
This study sustains [131I]ICF01012 as a good candidate for melanoma TRT and open perspectives for personalized dosimetry calculation during phase I clinical transfer.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1002/mp.13165</identifier><identifier>PMID: 30179267</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>Animals ; Cancer ; dosimetry ; Female ; GATE ; Humans ; imaging ; Iodine Radioisotopes - therapeutic use ; Life Sciences ; Male ; Melanoma - diagnostic imaging ; Melanoma - metabolism ; Melanoma - radiotherapy ; pigmented melanoma ; Quinoxalines - pharmacokinetics ; Quinoxalines - therapeutic use ; Rabbits ; Radiometry ; Radiotherapy Dosage ; Single Photon Emission Computed Tomography Computed Tomography ; Software ; targeted radionuclide therapy ; Tissue Distribution</subject><ispartof>Medical physics (Lancaster), 2018-11, Vol.45 (11), p.5251-5262</ispartof><rights>2018 American Association of Physicists in Medicine</rights><rights>2018 American Association of Physicists in Medicine.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3555-7b830b639fce6f4dc9bff6ace56a0d85ed3e0fc80bf73541f1528ec27de8179b3</citedby><cites>FETCH-LOGICAL-c3555-7b830b639fce6f4dc9bff6ace56a0d85ed3e0fc80bf73541f1528ec27de8179b3</cites><orcidid>0000-0001-7162-8450 ; 0000-0001-9043-5857</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmp.13165$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmp.13165$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30179267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01925049$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Jouberton, Elodie</creatorcontrib><creatorcontrib>Perrot, Yann</creatorcontrib><creatorcontrib>Dirat, Béatrice</creatorcontrib><creatorcontrib>Billoux, Tommy</creatorcontrib><creatorcontrib>Auzeloux, Philippe</creatorcontrib><creatorcontrib>Cachin, Florent</creatorcontrib><creatorcontrib>Chezal, Jean‐Michel</creatorcontrib><creatorcontrib>Filaire, Marc</creatorcontrib><creatorcontrib>Labarre, Pierre</creatorcontrib><creatorcontrib>Miot‐Noirault, Elisabeth</creatorcontrib><creatorcontrib>Millardet, Corinne</creatorcontrib><creatorcontrib>Valla, Clémence</creatorcontrib><creatorcontrib>Vidal, Aurélien</creatorcontrib><creatorcontrib>Degoul, Françoise</creatorcontrib><creatorcontrib>Maigne, Lydia</creatorcontrib><title>Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose
Dosimetry for melanoma‐targeted radionuclide therapy (TRT) with [131I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT‐CT imaging and ex vivo measurements.
Material and Methods
Ex vivo biodistribution (i.v. injection: 370 kBq/kg, n = 2 per point) is performed on blood, eyes, brain, lung, liver, kidneys, heart, stomach, and spleen. Dosimetry calculations follow the MIRD formalism: S values are calculated from CT images using the GATE Monte Carlo platform and activity distributions are obtained from SPECT‐CT imaging (i.v. injection: 37 MBq/kg n = 3 per point). A specific study is presented to assess dose to human retina.
Results
Time‐integrated activities based on SPECT‐CT are in accordance with ex vivo measurements except for spleen. Doses to liver and eyes are the most significant, with respectively, 6.38 ± 0.50 Gy/GBq (evaluated through SPECT‐CT imaging) and 45.8 ± 7.9 Gy/GBq (evaluated through ex vivo measurements). Characterization of ocular [131I]ICF01012 biodistribution in rabbits and quantification of melanin allowed to assess a dose of 3.07 ± 0.70 Gy/GBq to human retina.
Conclusion
This study sustains [131I]ICF01012 as a good candidate for melanoma TRT and open perspectives for personalized dosimetry calculation during phase I clinical transfer.</description><subject>Animals</subject><subject>Cancer</subject><subject>dosimetry</subject><subject>Female</subject><subject>GATE</subject><subject>Humans</subject><subject>imaging</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Melanoma - diagnostic imaging</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - radiotherapy</subject><subject>pigmented melanoma</subject><subject>Quinoxalines - pharmacokinetics</subject><subject>Quinoxalines - therapeutic use</subject><subject>Rabbits</subject><subject>Radiometry</subject><subject>Radiotherapy Dosage</subject><subject>Single Photon Emission Computed Tomography Computed Tomography</subject><subject>Software</subject><subject>targeted radionuclide therapy</subject><subject>Tissue Distribution</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2LFDEQhoMo7rgK_gLJUQ-9Vjqd_vA2DO7uwIgiehIJ6aTiRDqdNkkrw_55e-11PXkqKJ56qKqXkOcMLhhA-dpPF4yzWjwgm7JqeFGV0D0kG4CuKsoKxBl5ktJ3AKi5gMfkjANrurJuNuTmozJOZRdGakJyHnM80WDpl8W3_7rfXQIDVlI30qj63uX0hm6naXB6ncmBZhW_YUazAGZpzXpwBmk-YlTTidoQ6XH2aqQeBzUGr2iOqLLHMT8lj6waEj67q-fk8-XbT7vr4vD-ar_bHgrNhRBF07cc-pp3VmNtK6O73tpaaRS1AtMKNBzB6hZ623BRMctE2aIuG4PtcmbPz8mr1XtUg5yi8yqeZFBOXm8P8rYHrCsFVN1PtrAvV3aK4ceMKUvvksZh2R3DnOTy2K7ivBX1P1THkFJEe-9mIG9jkX6Sf2JZ0Bd31rn3aO7BvzksQLECv9yAp_-K5LsPq_A3FPSVqQ</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Jouberton, Elodie</creator><creator>Perrot, Yann</creator><creator>Dirat, Béatrice</creator><creator>Billoux, Tommy</creator><creator>Auzeloux, Philippe</creator><creator>Cachin, Florent</creator><creator>Chezal, Jean‐Michel</creator><creator>Filaire, Marc</creator><creator>Labarre, Pierre</creator><creator>Miot‐Noirault, Elisabeth</creator><creator>Millardet, Corinne</creator><creator>Valla, Clémence</creator><creator>Vidal, Aurélien</creator><creator>Degoul, Françoise</creator><creator>Maigne, Lydia</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7162-8450</orcidid><orcidid>https://orcid.org/0000-0001-9043-5857</orcidid></search><sort><creationdate>201811</creationdate><title>Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment</title><author>Jouberton, Elodie ; Perrot, Yann ; Dirat, Béatrice ; Billoux, Tommy ; Auzeloux, Philippe ; Cachin, Florent ; Chezal, Jean‐Michel ; Filaire, Marc ; Labarre, Pierre ; Miot‐Noirault, Elisabeth ; Millardet, Corinne ; Valla, Clémence ; Vidal, Aurélien ; Degoul, Françoise ; Maigne, Lydia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3555-7b830b639fce6f4dc9bff6ace56a0d85ed3e0fc80bf73541f1528ec27de8179b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>dosimetry</topic><topic>Female</topic><topic>GATE</topic><topic>Humans</topic><topic>imaging</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Melanoma - diagnostic imaging</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - radiotherapy</topic><topic>pigmented melanoma</topic><topic>Quinoxalines - pharmacokinetics</topic><topic>Quinoxalines - therapeutic use</topic><topic>Rabbits</topic><topic>Radiometry</topic><topic>Radiotherapy Dosage</topic><topic>Single Photon Emission Computed Tomography Computed Tomography</topic><topic>Software</topic><topic>targeted radionuclide therapy</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jouberton, Elodie</creatorcontrib><creatorcontrib>Perrot, Yann</creatorcontrib><creatorcontrib>Dirat, Béatrice</creatorcontrib><creatorcontrib>Billoux, Tommy</creatorcontrib><creatorcontrib>Auzeloux, Philippe</creatorcontrib><creatorcontrib>Cachin, Florent</creatorcontrib><creatorcontrib>Chezal, Jean‐Michel</creatorcontrib><creatorcontrib>Filaire, Marc</creatorcontrib><creatorcontrib>Labarre, Pierre</creatorcontrib><creatorcontrib>Miot‐Noirault, Elisabeth</creatorcontrib><creatorcontrib>Millardet, Corinne</creatorcontrib><creatorcontrib>Valla, Clémence</creatorcontrib><creatorcontrib>Vidal, Aurélien</creatorcontrib><creatorcontrib>Degoul, Françoise</creatorcontrib><creatorcontrib>Maigne, Lydia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jouberton, Elodie</au><au>Perrot, Yann</au><au>Dirat, Béatrice</au><au>Billoux, Tommy</au><au>Auzeloux, Philippe</au><au>Cachin, Florent</au><au>Chezal, Jean‐Michel</au><au>Filaire, Marc</au><au>Labarre, Pierre</au><au>Miot‐Noirault, Elisabeth</au><au>Millardet, Corinne</au><au>Valla, Clémence</au><au>Vidal, Aurélien</au><au>Degoul, Françoise</au><au>Maigne, Lydia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2018-11</date><risdate>2018</risdate><volume>45</volume><issue>11</issue><spage>5251</spage><epage>5262</epage><pages>5251-5262</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><abstract>Purpose
Dosimetry for melanoma‐targeted radionuclide therapy (TRT) with [131I]ICF01012, a melanin ligand, has been previously evaluated in mice bearing melanomas. In this study, activity distribution and dosimetry are performed on healthy rabbits (Fauve de Bourgogne) using SPECT‐CT imaging and ex vivo measurements.
Material and Methods
Ex vivo biodistribution (i.v. injection: 370 kBq/kg, n = 2 per point) is performed on blood, eyes, brain, lung, liver, kidneys, heart, stomach, and spleen. Dosimetry calculations follow the MIRD formalism: S values are calculated from CT images using the GATE Monte Carlo platform and activity distributions are obtained from SPECT‐CT imaging (i.v. injection: 37 MBq/kg n = 3 per point). A specific study is presented to assess dose to human retina.
Results
Time‐integrated activities based on SPECT‐CT are in accordance with ex vivo measurements except for spleen. Doses to liver and eyes are the most significant, with respectively, 6.38 ± 0.50 Gy/GBq (evaluated through SPECT‐CT imaging) and 45.8 ± 7.9 Gy/GBq (evaluated through ex vivo measurements). Characterization of ocular [131I]ICF01012 biodistribution in rabbits and quantification of melanin allowed to assess a dose of 3.07 ± 0.70 Gy/GBq to human retina.
Conclusion
This study sustains [131I]ICF01012 as a good candidate for melanoma TRT and open perspectives for personalized dosimetry calculation during phase I clinical transfer.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>30179267</pmid><doi>10.1002/mp.13165</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-7162-8450</orcidid><orcidid>https://orcid.org/0000-0001-9043-5857</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0094-2405 |
| ispartof | Medical physics (Lancaster), 2018-11, Vol.45 (11), p.5251-5262 |
| issn | 0094-2405 2473-4209 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_01925049v1 |
| source | MEDLINE; Wiley Online Library; Alma/SFX Local Collection |
| subjects | Animals Cancer dosimetry Female GATE Humans imaging Iodine Radioisotopes - therapeutic use Life Sciences Male Melanoma - diagnostic imaging Melanoma - metabolism Melanoma - radiotherapy pigmented melanoma Quinoxalines - pharmacokinetics Quinoxalines - therapeutic use Rabbits Radiometry Radiotherapy Dosage Single Photon Emission Computed Tomography Computed Tomography Software targeted radionuclide therapy Tissue Distribution |
| title | Radiation dosimetry of [131I]ICF01012 in rabbits: Application to targeted radionuclide therapy for human melanoma treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A31%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Radiation%20dosimetry%20of%20%5B131I%5DICF01012%20in%20rabbits:%20Application%20to%20targeted%20radionuclide%20therapy%20for%20human%20melanoma%20treatment&rft.jtitle=Medical%20physics%20(Lancaster)&rft.au=Jouberton,%20Elodie&rft.date=2018-11&rft.volume=45&rft.issue=11&rft.spage=5251&rft.epage=5262&rft.pages=5251-5262&rft.issn=0094-2405&rft.eissn=2473-4209&rft_id=info:doi/10.1002/mp.13165&rft_dat=%3Cproquest_hal_p%3E2099433856%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2099433856&rft_id=info:pmid/30179267&rfr_iscdi=true |