Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space

Highlights • Innate-like γδ T cell functions are pre-programmed in the thymus. • TCR signaling induces a regulatory network in γδ T cell development. • Distinct epigenetic mechanisms underlie the differentiation of γδ T cell subsets. • γδ T cell subsets show different degrees of functional stability...

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Veröffentlicht in:Seminars in immunology 2015-02, Vol.27 (1), p.19-25
Hauptverfasser: Schmolka, Nina, Wencker, Mélanie, Hayday, Adrian C, Silva-Santos, Bruno
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Bacteriology
Cell Differentiation
Epigenesis, Genetic
Humans
Immunology
Life Sciences
Microbiology and Parasitology
Pro-inflammatory cytokines
Receptors, Antigen, T-Cell, gamma-delta - metabolism
T cell development
T-Lymphocytes - cytology
T-Lymphocytes - immunology
Thymus Gland - cytology
Transcription, Genetic
Virology
γδ T cells
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Zusammenfassung:Highlights • Innate-like γδ T cell functions are pre-programmed in the thymus. • TCR signaling induces a regulatory network in γδ T cell development. • Distinct epigenetic mechanisms underlie the differentiation of γδ T cell subsets. • γδ T cell subsets show different degrees of functional stability versus plasticity in the periphery.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2015.01.001