5'- vs. 3'-end sugar conformational control in shaping up dinucleotides

5'- vs. 3'-end sugar conformational control in shaping up dinucleotides

The 5'-end N-sugar puckering is currently believed to govern the intramolecular dinucleotide stacking. We demonstrate that if this 5'-conformation is indeed important in shaping up dinucleotide structures, the 3'-end sugar conformation can either potentiate or cancel the stacking capa...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-08, Vol.51 (62), p.12381-12383
Hauptverfasser: Jakhlal, J, Coantic-Castex, S, Denhez, C, Petermann, C, Martinez, A, Harakat, D, Guillaume, D, Clivio, P
Format: Artikel
Sprache:eng
Schlagworte:
Carbohydrate Conformation
Chemical Sciences
Circular Dichroism
Dinucleoside Phosphates - chemistry
Organic chemistry
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Zusammenfassung:The 5'-end N-sugar puckering is currently believed to govern the intramolecular dinucleotide stacking. We demonstrate that if this 5'-conformation is indeed important in shaping up dinucleotide structures, the 3'-end sugar conformation can either potentiate or cancel the stacking capacity induced by the 5'-end N-sugar conformation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc04212g