Role of the left frontal aslant tract in stuttering: a brain stimulation and tractographic study

The neural correlates of stuttering are to date incompletely understood. Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of wh...

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Veröffentlicht in:Journal of neurology 2016-01, Vol.263 (1), p.157-167
Hauptverfasser: Kemerdere, Rahsan, de Champfleur, Nicolas Menjot, Deverdun, Jérémy, Cochereau, Jérôme, Moritz-Gasser, Sylvie, Herbet, Guillaume, Duffau, Hugues
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container_issue 1
container_start_page 157
container_title Journal of neurology
container_volume 263
creator Kemerdere, Rahsan
de Champfleur, Nicolas Menjot
Deverdun, Jérémy
Cochereau, Jérôme
Moritz-Gasser, Sylvie
Herbet, Guillaume
Duffau, Hugues
description The neural correlates of stuttering are to date incompletely understood. Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of white matter fibers in stuttering. Axonal stimulation during awake surgery provides a unique opportunity to study the functional role of structural connectivity. Here, our goal was to investigate the white matter tracts implicated in stuttering, by combining direct electrostimulation mapping and postoperative tractography imaging, with a special focus on the left frontal aslant tract. Eight patients with no preoperative stuttering underwent awake surgery for a left frontal low-grade glioma. Intraoperative cortical and axonal electrical mapping was used to interfere in speech processing and subsequently provoke stuttering. We further assessed the relationship between the subcortical sites leading to stuttering and the spatial course of the frontal aslant tract. All patients experienced intraoperative stuttering during axonal electrostimulation. On postsurgical tractographies, the subcortical distribution of stimulated sites matched the topographical position of the left frontal aslant tract. This white matter pathway was preserved during surgery, and no patients had postoperative stuttering. For the first time to our knowledge, by using direct axonal stimulation combined with postoperative tractography, we provide original data supporting a pivotal role of the left frontal aslant tract in stuttering. We propose that this speech disorder could be the result of a disconnection within a large-scale cortico-subcortical circuit subserving speech motor control.
doi_str_mv 10.1007/s00415-015-7949-3
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subjects Adult
Diffusion Tensor Imaging
Electric Stimulation
Female
Follow-Up Studies
Frontal Lobe - anatomy & histology
Frontal Lobe - physiopathology
Frontal Lobe - surgery
Human health and pathology
Humans
Intraoperative Neurophysiological Monitoring
Intraoperative Period
Life Sciences
Male
Medicine
Medicine & Public Health
Middle Aged
Neural Pathways - anatomy & histology
Neural Pathways - physiopathology
Neurology
Neurons and Cognition
Neuroradiology
Neurosciences
Original Communication
Speech disorders
Stuttering
Stuttering - physiopathology
Surgery
White Matter - anatomy & histology
White Matter - physiopathology
Young Adult
title Role of the left frontal aslant tract in stuttering: a brain stimulation and tractographic study
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