Role of the left frontal aslant tract in stuttering: a brain stimulation and tractographic study
The neural correlates of stuttering are to date incompletely understood. Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of wh...
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Veröffentlicht in: | Journal of neurology 2016-01, Vol.263 (1), p.157-167 |
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description | The neural correlates of stuttering are to date incompletely understood. Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of white matter fibers in stuttering. Axonal stimulation during awake surgery provides a unique opportunity to study the functional role of structural connectivity. Here, our goal was to investigate the white matter tracts implicated in stuttering, by combining direct electrostimulation mapping and postoperative tractography imaging, with a special focus on the left frontal aslant tract. Eight patients with no preoperative stuttering underwent awake surgery for a left frontal low-grade glioma. Intraoperative cortical and axonal electrical mapping was used to interfere in speech processing and subsequently provoke stuttering. We further assessed the relationship between the subcortical sites leading to stuttering and the spatial course of the frontal aslant tract. All patients experienced intraoperative stuttering during axonal electrostimulation. On postsurgical tractographies, the subcortical distribution of stimulated sites matched the topographical position of the left frontal aslant tract. This white matter pathway was preserved during surgery, and no patients had postoperative stuttering. For the first time to our knowledge, by using direct axonal stimulation combined with postoperative tractography, we provide original data supporting a pivotal role of the left frontal aslant tract in stuttering. We propose that this speech disorder could be the result of a disconnection within a large-scale cortico-subcortical circuit subserving speech motor control. |
doi_str_mv | 10.1007/s00415-015-7949-3 |
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Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of white matter fibers in stuttering. Axonal stimulation during awake surgery provides a unique opportunity to study the functional role of structural connectivity. Here, our goal was to investigate the white matter tracts implicated in stuttering, by combining direct electrostimulation mapping and postoperative tractography imaging, with a special focus on the left frontal aslant tract. Eight patients with no preoperative stuttering underwent awake surgery for a left frontal low-grade glioma. Intraoperative cortical and axonal electrical mapping was used to interfere in speech processing and subsequently provoke stuttering. We further assessed the relationship between the subcortical sites leading to stuttering and the spatial course of the frontal aslant tract. All patients experienced intraoperative stuttering during axonal electrostimulation. On postsurgical tractographies, the subcortical distribution of stimulated sites matched the topographical position of the left frontal aslant tract. This white matter pathway was preserved during surgery, and no patients had postoperative stuttering. For the first time to our knowledge, by using direct axonal stimulation combined with postoperative tractography, we provide original data supporting a pivotal role of the left frontal aslant tract in stuttering. We propose that this speech disorder could be the result of a disconnection within a large-scale cortico-subcortical circuit subserving speech motor control.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-015-7949-3</identifier><identifier>PMID: 26559819</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Diffusion Tensor Imaging ; Electric Stimulation ; Female ; Follow-Up Studies ; Frontal Lobe - anatomy & histology ; Frontal Lobe - physiopathology ; Frontal Lobe - surgery ; Human health and pathology ; Humans ; Intraoperative Neurophysiological Monitoring ; Intraoperative Period ; Life Sciences ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neural Pathways - anatomy & histology ; Neural Pathways - physiopathology ; Neurology ; Neurons and Cognition ; Neuroradiology ; Neurosciences ; Original Communication ; Speech disorders ; Stuttering ; Stuttering - physiopathology ; Surgery ; White Matter - anatomy & histology ; White Matter - physiopathology ; Young Adult</subject><ispartof>Journal of neurology, 2016-01, Vol.263 (1), p.157-167</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-d44642d4a31b25b9ca98ba8086c50714818918480467c3a447f05a17fc9dba03</citedby><cites>FETCH-LOGICAL-c575t-d44642d4a31b25b9ca98ba8086c50714818918480467c3a447f05a17fc9dba03</cites><orcidid>0000-0002-4098-5962 ; 0000-0001-6690-254X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-015-7949-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-015-7949-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26559819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-01886885$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kemerdere, Rahsan</creatorcontrib><creatorcontrib>de Champfleur, Nicolas Menjot</creatorcontrib><creatorcontrib>Deverdun, Jérémy</creatorcontrib><creatorcontrib>Cochereau, Jérôme</creatorcontrib><creatorcontrib>Moritz-Gasser, Sylvie</creatorcontrib><creatorcontrib>Herbet, Guillaume</creatorcontrib><creatorcontrib>Duffau, Hugues</creatorcontrib><title>Role of the left frontal aslant tract in stuttering: a brain stimulation and tractographic study</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description>The neural correlates of stuttering are to date incompletely understood. Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of white matter fibers in stuttering. Axonal stimulation during awake surgery provides a unique opportunity to study the functional role of structural connectivity. Here, our goal was to investigate the white matter tracts implicated in stuttering, by combining direct electrostimulation mapping and postoperative tractography imaging, with a special focus on the left frontal aslant tract. Eight patients with no preoperative stuttering underwent awake surgery for a left frontal low-grade glioma. Intraoperative cortical and axonal electrical mapping was used to interfere in speech processing and subsequently provoke stuttering. We further assessed the relationship between the subcortical sites leading to stuttering and the spatial course of the frontal aslant tract. All patients experienced intraoperative stuttering during axonal electrostimulation. On postsurgical tractographies, the subcortical distribution of stimulated sites matched the topographical position of the left frontal aslant tract. This white matter pathway was preserved during surgery, and no patients had postoperative stuttering. For the first time to our knowledge, by using direct axonal stimulation combined with postoperative tractography, we provide original data supporting a pivotal role of the left frontal aslant tract in stuttering. We propose that this speech disorder could be the result of a disconnection within a large-scale cortico-subcortical circuit subserving speech motor control.</description><subject>Adult</subject><subject>Diffusion Tensor Imaging</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Frontal Lobe - anatomy & histology</subject><subject>Frontal Lobe - physiopathology</subject><subject>Frontal Lobe - surgery</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Intraoperative Neurophysiological Monitoring</subject><subject>Intraoperative Period</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neural Pathways - anatomy & histology</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurology</subject><subject>Neurons and Cognition</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Original Communication</subject><subject>Speech disorders</subject><subject>Stuttering</subject><subject>Stuttering - physiopathology</subject><subject>Surgery</subject><subject>White Matter - anatomy & histology</subject><subject>White Matter - physiopathology</subject><subject>Young Adult</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkVFrFTEQhYNY7G31B_giAV_sw9bJJtkkvpXSWuGCIH2Ps9ls75a9m2uSLfTfm3VrEUHwIQQm3zkzk0PIWwbnDEB9TACCyQrKUUaYir8gGyZ4XTEhzUuyAS6gklyKY3KS0j0A6PLwihzXjZRGM7Mh37-F0dPQ07zzdPR9pn0MU8aRYhpxyjRHdJkOE015ztnHYbr7RJG2EX_Vhv08Yh7CRHHqVjjcRTzsBrcousfX5KjHMfk3T_cpub2-ur28qbZfP3-5vNhWTiqZq06IRtSdQM7aWrbGodEtatCNk6CY0EwbpoUG0SjHUQjVg0Smeme6FoGfkrPVdoejPcRhj_HRBhzszcXWLjVgWjdaywdW2A8re4jhx-xTtvshOT-WfX2Yk2WqkUYpI_X_oGB4zbkp6Pu_0Pswx6nsXChpQJf_rgvFVsrFkFL0_fOwDOwSql1DLfNKu4RqedG8e3Ke273vnhW_UyxAvQLpsOTj4x-t_-n6ExQ8qjk</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Kemerdere, Rahsan</creator><creator>de Champfleur, Nicolas Menjot</creator><creator>Deverdun, Jérémy</creator><creator>Cochereau, Jérôme</creator><creator>Moritz-Gasser, Sylvie</creator><creator>Herbet, Guillaume</creator><creator>Duffau, Hugues</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><general>Springer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-4098-5962</orcidid><orcidid>https://orcid.org/0000-0001-6690-254X</orcidid></search><sort><creationdate>20160101</creationdate><title>Role of the left frontal aslant tract in stuttering: a brain stimulation and tractographic study</title><author>Kemerdere, Rahsan ; 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Although the possible involvement of the basal ganglia, the cerebellum and certain parts of the cerebral cortex in this speech disorder has previously been reported, there are still not many studies investigating the role of white matter fibers in stuttering. Axonal stimulation during awake surgery provides a unique opportunity to study the functional role of structural connectivity. Here, our goal was to investigate the white matter tracts implicated in stuttering, by combining direct electrostimulation mapping and postoperative tractography imaging, with a special focus on the left frontal aslant tract. Eight patients with no preoperative stuttering underwent awake surgery for a left frontal low-grade glioma. Intraoperative cortical and axonal electrical mapping was used to interfere in speech processing and subsequently provoke stuttering. We further assessed the relationship between the subcortical sites leading to stuttering and the spatial course of the frontal aslant tract. All patients experienced intraoperative stuttering during axonal electrostimulation. On postsurgical tractographies, the subcortical distribution of stimulated sites matched the topographical position of the left frontal aslant tract. This white matter pathway was preserved during surgery, and no patients had postoperative stuttering. For the first time to our knowledge, by using direct axonal stimulation combined with postoperative tractography, we provide original data supporting a pivotal role of the left frontal aslant tract in stuttering. We propose that this speech disorder could be the result of a disconnection within a large-scale cortico-subcortical circuit subserving speech motor control.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26559819</pmid><doi>10.1007/s00415-015-7949-3</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4098-5962</orcidid><orcidid>https://orcid.org/0000-0001-6690-254X</orcidid></addata></record> |
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subjects | Adult Diffusion Tensor Imaging Electric Stimulation Female Follow-Up Studies Frontal Lobe - anatomy & histology Frontal Lobe - physiopathology Frontal Lobe - surgery Human health and pathology Humans Intraoperative Neurophysiological Monitoring Intraoperative Period Life Sciences Male Medicine Medicine & Public Health Middle Aged Neural Pathways - anatomy & histology Neural Pathways - physiopathology Neurology Neurons and Cognition Neuroradiology Neurosciences Original Communication Speech disorders Stuttering Stuttering - physiopathology Surgery White Matter - anatomy & histology White Matter - physiopathology Young Adult |
title | Role of the left frontal aslant tract in stuttering: a brain stimulation and tractographic study |
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