Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia
Abstract Sixteen healthy exercise trained participants underwent the following three, 10-h exposures in a randomized manner: (1) Hypobaric hypoxia (HH; 3450 m terrestrial altitude) (2) Normobaric hypoxia (NH; 3450 m simulated altitude) and (3) Normobaric normoxia (NN). Plasma oxidative stress (malon...
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| Veröffentlicht in: | Respiratory physiology & neurobiology 2016-03, Vol.223, p.23-27 |
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| creator | Ribon, A Pialoux, V Saugy, J.J Rupp, T Faiss, R Debevec, T Millet, G.P |
| description | Abstract Sixteen healthy exercise trained participants underwent the following three, 10-h exposures in a randomized manner: (1) Hypobaric hypoxia (HH; 3450 m terrestrial altitude) (2) Normobaric hypoxia (NH; 3450 m simulated altitude) and (3) Normobaric normoxia (NN). Plasma oxidative stress (malondialdehyde, MDA; advanced oxidation protein products, AOPP) and antioxidant markers (superoxide dismutase, SOD; glutathione peroxidase, GPX; catalase; ferric reducing antioxidant power, FRAP) were measured before and after each exposure. MDA was significantly higher after HH compared to NN condition (+24%). SOD and GPX activities were increased (vs. before; +29% and +54%) while FRAP was decreased (vs. before; −34%) only after 10 h of HH. AOPP significantly increased after 10 h for NH (vs. before; +83%), and HH (vs. before; +99%) whereas it remained stable in NN. These results provide evidence that prooxidant/antioxidant balance was impaired to a greater degree following acute exposure to terrestrial (HH) vs. simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences. |
| doi_str_mv | 10.1016/j.resp.2015.12.008 |
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Plasma oxidative stress (malondialdehyde, MDA; advanced oxidation protein products, AOPP) and antioxidant markers (superoxide dismutase, SOD; glutathione peroxidase, GPX; catalase; ferric reducing antioxidant power, FRAP) were measured before and after each exposure. MDA was significantly higher after HH compared to NN condition (+24%). SOD and GPX activities were increased (vs. before; +29% and +54%) while FRAP was decreased (vs. before; −34%) only after 10 h of HH. AOPP significantly increased after 10 h for NH (vs. before; +83%), and HH (vs. before; +99%) whereas it remained stable in NN. These results provide evidence that prooxidant/antioxidant balance was impaired to a greater degree following acute exposure to terrestrial (HH) vs. simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences.</description><identifier>ISSN: 1569-9048</identifier><identifier>EISSN: 1878-1519</identifier><identifier>DOI: 10.1016/j.resp.2015.12.008</identifier><identifier>PMID: 26732282</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Altitude ; Antioxidant enzymes ; Atmospheric Pressure ; Barometric pressure ; Humans ; Hypoxia - blood ; Life Sciences ; Lipid peroxidation ; Male ; Medical Education ; Oxidative Stress - physiology ; Oxidoreductases - blood ; Pulmonary/Respiratory</subject><ispartof>Respiratory physiology & neurobiology, 2016-03, Vol.223, p.23-27</ispartof><rights>Elsevier B.V.</rights><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-d1f765f9c5dd399834bff68e5340c832ce4416fa47ddc2995449ec2d58a56f213</citedby><cites>FETCH-LOGICAL-c511t-d1f765f9c5dd399834bff68e5340c832ce4416fa47ddc2995449ec2d58a56f213</cites><orcidid>0000-0003-4911-874X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.resp.2015.12.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26732282$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-lyon1.hal.science/hal-01883917$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ribon, A</creatorcontrib><creatorcontrib>Pialoux, V</creatorcontrib><creatorcontrib>Saugy, J.J</creatorcontrib><creatorcontrib>Rupp, T</creatorcontrib><creatorcontrib>Faiss, R</creatorcontrib><creatorcontrib>Debevec, T</creatorcontrib><creatorcontrib>Millet, G.P</creatorcontrib><title>Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia</title><title>Respiratory physiology & neurobiology</title><addtitle>Respir Physiol Neurobiol</addtitle><description>Abstract Sixteen healthy exercise trained participants underwent the following three, 10-h exposures in a randomized manner: (1) Hypobaric hypoxia (HH; 3450 m terrestrial altitude) (2) Normobaric hypoxia (NH; 3450 m simulated altitude) and (3) Normobaric normoxia (NN). Plasma oxidative stress (malondialdehyde, MDA; advanced oxidation protein products, AOPP) and antioxidant markers (superoxide dismutase, SOD; glutathione peroxidase, GPX; catalase; ferric reducing antioxidant power, FRAP) were measured before and after each exposure. MDA was significantly higher after HH compared to NN condition (+24%). SOD and GPX activities were increased (vs. before; +29% and +54%) while FRAP was decreased (vs. before; −34%) only after 10 h of HH. AOPP significantly increased after 10 h for NH (vs. before; +83%), and HH (vs. before; +99%) whereas it remained stable in NN. These results provide evidence that prooxidant/antioxidant balance was impaired to a greater degree following acute exposure to terrestrial (HH) vs. simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences.</description><subject>Adult</subject><subject>Altitude</subject><subject>Antioxidant enzymes</subject><subject>Atmospheric Pressure</subject><subject>Barometric pressure</subject><subject>Humans</subject><subject>Hypoxia - blood</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Male</subject><subject>Medical Education</subject><subject>Oxidative Stress - physiology</subject><subject>Oxidoreductases - blood</subject><subject>Pulmonary/Respiratory</subject><issn>1569-9048</issn><issn>1878-1519</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kkFv1DAQhSMEoqXwBzigHOGQ4LHj2JYQUlWVFmklDsDZ8toT1ksSBztZdf89DttWggMnj-z3PkvvTVG8BlIDgfb9vo6YppoS4DXQmhD5pDgHKWQFHNTTPPNWVYo08qx4kdKeEBAg2PPijLaCUSrpeaGv76aQlojlHMrdcQpbE739M915U-YPln5OpR_Lnf-xw1jma2dmf8Ayzfk1lTYMk4noVsAY4vA34WXxrDN9wlf350Xx_dP1t6vbavPl5vPV5aayHGCuHHSi5Z2y3DmmlGTNtutaiZw1xEpGLTYNtJ1phHOWKsWbRqGljkvD244Cuyjenbg70-sp-sHEow7G69vLjV7vCEjJFIjDqn170k4x_FowzXrwyWLfmxHDkjSIFkROh5MspSepjSGliN0jG4heS9B7vZag1xI0UJ1LyKY39_xlO6B7tDykngUfTgLMiRw8Rp2sx9Gi8xHtrF3w_-d__Mduez96a_qfeMS0D0scc9YadMoG_XVdg3ULgDNClBTsN1zurfw</recordid><startdate>20160301</startdate><enddate>20160301</enddate><creator>Ribon, A</creator><creator>Pialoux, V</creator><creator>Saugy, J.J</creator><creator>Rupp, T</creator><creator>Faiss, R</creator><creator>Debevec, T</creator><creator>Millet, G.P</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-4911-874X</orcidid></search><sort><creationdate>20160301</creationdate><title>Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia</title><author>Ribon, A ; Pialoux, V ; Saugy, J.J ; Rupp, T ; Faiss, R ; Debevec, T ; Millet, G.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-d1f765f9c5dd399834bff68e5340c832ce4416fa47ddc2995449ec2d58a56f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Altitude</topic><topic>Antioxidant enzymes</topic><topic>Atmospheric Pressure</topic><topic>Barometric pressure</topic><topic>Humans</topic><topic>Hypoxia - blood</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Male</topic><topic>Medical Education</topic><topic>Oxidative Stress - physiology</topic><topic>Oxidoreductases - blood</topic><topic>Pulmonary/Respiratory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ribon, A</creatorcontrib><creatorcontrib>Pialoux, V</creatorcontrib><creatorcontrib>Saugy, J.J</creatorcontrib><creatorcontrib>Rupp, T</creatorcontrib><creatorcontrib>Faiss, R</creatorcontrib><creatorcontrib>Debevec, T</creatorcontrib><creatorcontrib>Millet, G.P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Respiratory physiology & neurobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ribon, A</au><au>Pialoux, V</au><au>Saugy, J.J</au><au>Rupp, T</au><au>Faiss, R</au><au>Debevec, T</au><au>Millet, G.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia</atitle><jtitle>Respiratory physiology & neurobiology</jtitle><addtitle>Respir Physiol Neurobiol</addtitle><date>2016-03-01</date><risdate>2016</risdate><volume>223</volume><spage>23</spage><epage>27</epage><pages>23-27</pages><issn>1569-9048</issn><eissn>1878-1519</eissn><abstract>Abstract Sixteen healthy exercise trained participants underwent the following three, 10-h exposures in a randomized manner: (1) Hypobaric hypoxia (HH; 3450 m terrestrial altitude) (2) Normobaric hypoxia (NH; 3450 m simulated altitude) and (3) Normobaric normoxia (NN). Plasma oxidative stress (malondialdehyde, MDA; advanced oxidation protein products, AOPP) and antioxidant markers (superoxide dismutase, SOD; glutathione peroxidase, GPX; catalase; ferric reducing antioxidant power, FRAP) were measured before and after each exposure. MDA was significantly higher after HH compared to NN condition (+24%). SOD and GPX activities were increased (vs. before; +29% and +54%) while FRAP was decreased (vs. before; −34%) only after 10 h of HH. AOPP significantly increased after 10 h for NH (vs. before; +83%), and HH (vs. before; +99%) whereas it remained stable in NN. These results provide evidence that prooxidant/antioxidant balance was impaired to a greater degree following acute exposure to terrestrial (HH) vs. simulated altitude (NH) and that the chamber confinement (NN) did likely not explain these differences.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26732282</pmid><doi>10.1016/j.resp.2015.12.008</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4911-874X</orcidid></addata></record> |
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| subjects | Adult Altitude Antioxidant enzymes Atmospheric Pressure Barometric pressure Humans Hypoxia - blood Life Sciences Lipid peroxidation Male Medical Education Oxidative Stress - physiology Oxidoreductases - blood Pulmonary/Respiratory |
| title | Exposure to hypobaric hypoxia results in higher oxidative stress compared to normobaric hypoxia |
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