A convenient synthetic route to polyether-tagged cyclam ligands and their nickel derivatives

A convenient synthetic route to polyether-tagged cyclam ligands and their nickel derivatives

A specific strategy is described for the synthesis of stable polyethylene oxide tagged tetraazamacrocycles (PEO-cyclam) in five steps (overall yields for 12 and 13 48% and 22%, respectively). Various attempts via classical pathways demonstrated: (i) the low reactivity of PEG derivatives, and (ii) th...

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Veröffentlicht in:European journal of organic chemistry 1999, p.3257-3261
Hauptverfasser: Bellouard, F., Chuburu, F., Yaouanc, J.-J., Handel, H., Le Mest, Y.
Format: Artikel
Sprache:eng
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Chemical Sciences
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Zusammenfassung:A specific strategy is described for the synthesis of stable polyethylene oxide tagged tetraazamacrocycles (PEO-cyclam) in five steps (overall yields for 12 and 13 48% and 22%, respectively). Various attempts via classical pathways demonstrated: (i) the low reactivity of PEG derivatives, and (ii) the necessity of a stabiliser arm between the cyclam and the PEO chain. Nickel complexes have been prepared and characterised by electrochemistry.
ISSN:1434-193X
1099-0690
DOI:10.1002/(sici)1099-0690(199912)1999:12<3257::aid-ejoc3257>3.0.co;2-8