Phosphonolipids as non-viral vectors for gene therapy
Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoïetic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particular...
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| Veröffentlicht in: | European journal of medicinal chemistry 1998, Vol.33 (12), p.923-934 |
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| container_end_page | 934 |
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| container_issue | 12 |
| container_start_page | 923 |
| container_title | European journal of medicinal chemistry |
| container_volume | 33 |
| creator | Floch, Virginie Le Bolc'h, Gwénaëlle Gable-Guillaume, Christine Le Bris, Nathalie Yaouanc, Jean-Jacques des Abbayes, Hervé Férec, Claude Clément, Jean-Claude |
| description | Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoïetic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient. |
| doi_str_mv | 10.1016/S0223-5234(99)80017-8 |
| format | Article |
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In both cases, ammonium-phosphonates were particularly efficient.</description><subject>ammoniums</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemical Sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene therapy</subject><subject>Health. Pharmaceutical industry</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>non-viral transfection</subject><subject>phosphonolipids</subject><subject>polyamines</subject><issn>0223-5234</issn><issn>1768-3254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhoMouK7-BKEHD-6hOkmatDnJsvgFCwrqOUzT1EZqU5KlsP_e7lbWo6eB4Xnn4yHkksINBSpv34AxngrGs2ulFgUAzdPiiMxoLouUM5Edk9kBOSVnMX4BgJAAMyJeGx_7xne-db2rYoIx6XyXDi5gmwzWbHyISe1D8mk7m2waG7DfnpOTGttoL37rnHw83L-vntL1y-PzarlODc9hkworVKYKQS0vGasyFAKxzOh4R83qEhTy3ApZG4UZ54UQDCtaKiiklMyKjM_JYprbYKv74L4xbLVHp5-Wa73rja_mkDM50JEVE2uCjzHY-hCgoHee9N6T3knQSum9J12Muasp12M02NYBO-PiX1hmknEYsbsJs-O_g7NBR-NsZ2zlwmhJV979s-gHgUR6IA</recordid><startdate>1998</startdate><enddate>1998</enddate><creator>Floch, Virginie</creator><creator>Le Bolc'h, Gwénaëlle</creator><creator>Gable-Guillaume, Christine</creator><creator>Le Bris, Nathalie</creator><creator>Yaouanc, Jean-Jacques</creator><creator>des Abbayes, Hervé</creator><creator>Férec, Claude</creator><creator>Clément, Jean-Claude</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-6936-3876</orcidid><orcidid>https://orcid.org/0000-0002-2325-0710</orcidid></search><sort><creationdate>1998</creationdate><title>Phosphonolipids as non-viral vectors for gene therapy</title><author>Floch, Virginie ; Le Bolc'h, Gwénaëlle ; Gable-Guillaume, Christine ; Le Bris, Nathalie ; Yaouanc, Jean-Jacques ; des Abbayes, Hervé ; Férec, Claude ; Clément, Jean-Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-5e5949851e3b22d4a55aab41523f2fb09a37e56fc9a4338552ad1b9086662e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>ammoniums</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Chemical Sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene therapy</topic><topic>Health. Pharmaceutical industry</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>non-viral transfection</topic><topic>phosphonolipids</topic><topic>polyamines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Floch, Virginie</creatorcontrib><creatorcontrib>Le Bolc'h, Gwénaëlle</creatorcontrib><creatorcontrib>Gable-Guillaume, Christine</creatorcontrib><creatorcontrib>Le Bris, Nathalie</creatorcontrib><creatorcontrib>Yaouanc, Jean-Jacques</creatorcontrib><creatorcontrib>des Abbayes, Hervé</creatorcontrib><creatorcontrib>Férec, Claude</creatorcontrib><creatorcontrib>Clément, Jean-Claude</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>European journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Floch, Virginie</au><au>Le Bolc'h, Gwénaëlle</au><au>Gable-Guillaume, Christine</au><au>Le Bris, Nathalie</au><au>Yaouanc, Jean-Jacques</au><au>des Abbayes, Hervé</au><au>Férec, Claude</au><au>Clément, Jean-Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphonolipids as non-viral vectors for gene therapy</atitle><jtitle>European journal of medicinal chemistry</jtitle><date>1998</date><risdate>1998</risdate><volume>33</volume><issue>12</issue><spage>923</spage><epage>934</epage><pages>923-934</pages><issn>0223-5234</issn><eissn>1768-3254</eissn><coden>EJMCA5</coden><abstract>Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoïetic (K562) cell lines, and compared to commercially available references. 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| identifier | ISSN: 0223-5234 |
| ispartof | European journal of medicinal chemistry, 1998, Vol.33 (12), p.923-934 |
| issn | 0223-5234 1768-3254 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | ammoniums Biological and medical sciences Biotechnology Chemical Sciences Fundamental and applied biological sciences. Psychology Gene therapy Health. Pharmaceutical industry Industrial applications and implications. Economical aspects non-viral transfection phosphonolipids polyamines |
| title | Phosphonolipids as non-viral vectors for gene therapy |
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