Phosphonolipids as non-viral vectors for gene therapy

Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoïetic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particular...

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Veröffentlicht in:	European journal of medicinal chemistry 1998, Vol.33 (12), p.923-934
Hauptverfasser:	Floch, Virginie, Le Bolc'h, Gwénaëlle, Gable-Guillaume, Christine, Le Bris, Nathalie, Yaouanc, Jean-Jacques, des Abbayes, Hervé, Férec, Claude, Clément, Jean-Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	ammoniums Biological and medical sciences Biotechnology Chemical Sciences Fundamental and applied biological sciences. Psychology Gene therapy Health. Pharmaceutical industry Industrial applications and implications. Economical aspects non-viral transfection phosphonolipids polyamines
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Beschreibung
Zusammenfassung:	Several phosphonates with two fatty chains and different polar heads were synthesized and evaluated for their potential to transfer DNA into epithelial (COS-7) and hematopoïetic (K562) cell lines, and compared to commercially available references. In both cases, ammonium-phosphonates were particularly efficient.
ISSN:	0223-5234 1768-3254
DOI:	10.1016/S0223-5234(99)80017-8