Versatile Microfluidic Approach to Crystallization

We present a simple and easy-to-use microfluidic setup for the crystallization of mineral, organic, and biological materials. After briefly presenting the hydrodynamic properties of the setup, we test and validate it with viscous media by crystallizing a protein in an aqueous solution of PEG. We obt...

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Veröffentlicht in:Organic process research & development 2015-12, Vol.19 (12), p.1837-1841
Hauptverfasser: Zhang, S, Ferté, N, Candoni, N, Veesler, S
Format: Artikel
Sprache:eng
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Zusammenfassung:We present a simple and easy-to-use microfluidic setup for the crystallization of mineral, organic, and biological materials. After briefly presenting the hydrodynamic properties of the setup, we test and validate it with viscous media by crystallizing a protein in an aqueous solution of PEG. We obtain nucleation data in nanocrystallizers using a droplet-based method and precisely controlling input flows to test different crystallization conditions.
ISSN:1083-6160
1520-586X
DOI:10.1021/acs.oprd.5b00122