Both sunitinib and sorafenib are effective treatments for pheochromocytoma in a xenograft model

Highlights • Sunitinib and sorafenib inhibit the growth of pheochromocytoma cell xenografts. • Sunitinib and sorafenib inhibit tumor neo-angiogenesis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib induce apoptosis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib decreas...

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Veröffentlicht in:	Cancer letters 2014-10, Vol.352 (2), p.236-244
Hauptverfasser:	Denorme, M, Yon, L, Roux, C, Gonzalez, B.J, Baudin, E, Anouar, Y, Dubessy, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adrenal Gland Neoplasms - blood supply Adrenal Gland Neoplasms - drug therapy Adrenal Gland Neoplasms - enzymology Adrenal Gland Neoplasms - pathology Angiogenesis Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - pharmacology Animals Apoptosis Apoptosis - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Drug dosages FDA approval Gene expression Hematology, Oncology and Palliative Medicine Heterografts Indoles - administration & dosage Indoles - pharmacology Kinases Life Sciences Liver cancer Male Mice Mice, Nude Mortality Mutation Neoplasm Transplantation Neovascularization, Pathologic Niacinamide - administration & dosage Niacinamide - analogs & derivatives Niacinamide - pharmacology PC12 Cells Phenylurea Compounds - administration & dosage Phenylurea Compounds - pharmacology Pheochromocytoma Pheochromocytoma - blood supply Pheochromocytoma - drug therapy Pheochromocytoma - enzymology Pheochromocytoma - pathology Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Pyrroles - administration & dosage Pyrroles - pharmacology Rats Sorafenib Studies Sunitinib Therapy Time Factors Tumor Burden - drug effects Tumors Vascular endothelial growth factor Xenograft model
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Beschreibung
Zusammenfassung:	Highlights • Sunitinib and sorafenib inhibit the growth of pheochromocytoma cell xenografts. • Sunitinib and sorafenib inhibit tumor neo-angiogenesis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib induce apoptosis in pheochromocytoma cell xenografts. • Sunitinib and sorafenib decrease the viability of PC12 cells. • Sunitinib, but not sorafenib, exerts a pro-apoptotic effect in PC12 cells.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.07.005