Gold-Catalyzed Synthesis of Substituted 3‑Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols

Gold-Catalyzed Synthesis of Substituted 3‑Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols

A series of substituted 3-trifluoromethylpyrroles was obtained from trifluoromethylamino-ynol derivatives via a gold-catalyzed cyclization. Using fluorinated starting materials, after mesylation, allowed for the desired compounds to be obtained in good yields under mild conditions.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2017-12, Vol.82 (24), p.13708-13713
Hauptverfasser: Guieu, Benjamin, Le Roch, Myriam, David, Michèle, Gouault, Nicolas
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Chemical Sciences
Organic chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of substituted 3-trifluoromethylpyrroles was obtained from trifluoromethylamino-ynol derivatives via a gold-catalyzed cyclization. Using fluorinated starting materials, after mesylation, allowed for the desired compounds to be obtained in good yields under mild conditions.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b02567