Simple and convenient conversion of acridones into 9-unsubstituted acridines via acridanes using borane tetrahydrofuran complex

Simple and convenient conversion of acridones into 9-unsubstituted acridines via acridanes using borane tetrahydrofuran complex

A new method for the synthesis of 9-unsubstituted acridines from acridones using mild conditions is described. Various acridines bearing reduction-sensitive group(s) have been synthesized from the corresponding acridones using a two-step procedure that involved a commercially available borane comple...

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Veröffentlicht in:Tetrahedron letters 2009-12, Vol.50 (49), p.6894-6896
Hauptverfasser: Desbois, Nicolas, Szollosi, Anna, Maisonial, Aurélie, Weber, Valérie, Moreau, Emmanuel, Teulade, Jean-Claude, Chavignon, Olivier, Blache, Yves, Chezal, Jean Michel
Format: Artikel
Sprache:eng
Schlagworte:
Acridine
Acridone
Biodiversity and Ecology
Borane complex
Chemical Sciences
Coordination chemistry
Environmental Sciences
Medicinal Chemistry
Organic chemistry
Radiochemistry
Reduction
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Beschreibung
Zusammenfassung:A new method for the synthesis of 9-unsubstituted acridines from acridones using mild conditions is described. Various acridines bearing reduction-sensitive group(s) have been synthesized from the corresponding acridones using a two-step procedure that involved a commercially available borane complex reduction followed by an acridane oxidation.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2009.09.141