Bis-15-crown-5-ether-pillar[5]arene K+‑Responsive Channels

Bis-15-crown-5-ether-pillar[5]arene K+‑Responsive Channels

An artificial selective K+ channel is formed from the supramolecular organization on bis­(benzo-15-crown-5- ether-ureido)-pillar[5]­arene compound. This channel achieves a selectivity of SK+/Na+ = 5 for an initial transport rate of k K+ = 3.2 × 10–3 s–1. The cation-file diffusion occurs via selectiv...

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Veröffentlicht in:Organic letters 2017-03, Vol.19 (6), p.1438-1441
Hauptverfasser: Feng, Wei-Xu, Sun, Zhanhu, Zhang, Yan, Legrand, Yves-Marie, Petit, Eddy, Su, Cheng-Yong, Barboiu, Mihail
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
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Zusammenfassung:An artificial selective K+ channel is formed from the supramolecular organization on bis­(benzo-15-crown-5- ether-ureido)-pillar[5]­arene compound. This channel achieves a selectivity of SK+/Na+ = 5 for an initial transport rate of k K+ = 3.2 × 10–3 s–1. The cation-file diffusion occurs via selective macrocyclic-filters anchored on inactive supporting pillar[5]­arene relays. The sandwich-type binding geometry of the K+ cation by two 15-crown-5 moieties sites is a key feature influencing channel efficiency.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b00352