One-Pot Approach to Well-Defined Biomolecular Assemblies by Orthogonal Chemoselective Ligations
Click-click cyclopeptides: Well-defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)-mediated alkyne-azide cycloaddition reactions in a stepwise or in a one-pot approach. To illustrate this strategy, regioselective ligation of biologically relevant pept...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 2009-03, Vol.48 (14), p.2576-2579 |
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| container_issue | 14 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 48 |
| creator | Galibert, Mathieu Dumy, Pascal Boturyn, Didier |
| description | Click-click cyclopeptides: Well-defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)-mediated alkyne-azide cycloaddition reactions in a stepwise or in a one-pot approach. To illustrate this strategy, regioselective ligation of biologically relevant peptides onto a cyclopeptidic scaffold was performed. |
| doi_str_mv | 10.1002/anie.200806223 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2009-03, Vol.48 (14), p.2576-2579 |
| issn | 1433-7851 1521-3773 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alkynes - chemistry Azides - chemistry Catalysis Chemical Sciences chemoselectivity click chemistry copper Copper - chemistry Cyclization oximes Oximes - chemistry peptides Peptides - chemical synthesis Peptides - chemistry Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry |
| title | One-Pot Approach to Well-Defined Biomolecular Assemblies by Orthogonal Chemoselective Ligations |
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