One-Pot Approach to Well-Defined Biomolecular Assemblies by Orthogonal Chemoselective Ligations

Click-click cyclopeptides: Well-defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)-mediated alkyne-azide cycloaddition reactions in a stepwise or in a one-pot approach. To illustrate this strategy, regioselective ligation of biologically relevant pept...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-03, Vol.48 (14), p.2576-2579
Hauptverfasser:	Galibert, Mathieu, Dumy, Pascal, Boturyn, Didier
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Azides - chemistry Catalysis Chemical Sciences chemoselectivity click chemistry copper Copper - chemistry Cyclization oximes Oximes - chemistry peptides Peptides - chemical synthesis Peptides - chemistry Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry
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Beschreibung
Zusammenfassung:	Click-click cyclopeptides: Well-defined biomolecular assemblies are synthesized using orthogonal oxime bond formation and copper(I)-mediated alkyne-azide cycloaddition reactions in a stepwise or in a one-pot approach. To illustrate this strategy, regioselective ligation of biologically relevant peptides onto a cyclopeptidic scaffold was performed.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200806223