Photodynamic therapy using methylene blue in lung adenocarcinoma xenograft and hamster cheek pouch induced squamous cell carcinoma

Photodynamic therapy using methylene blue in lung adenocarcinoma xenograft and hamster cheek pouch induced squamous cell carcinoma

Highlights • Methylene blue (MB) is evaluated as a photodynamic agent for cancer treatment of lung adenocarcinoma xenograft and Hamster cheek pouch induced squamous cell carcinoma. • MB-PDT was performed in-vivo on lung cancer xenograft in nude mice and in the cheek pouch model. • MB-PDT induced a s...

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Veröffentlicht in:Photodiagnosis and photodynamic therapy 2016-09, Vol.15, p.109-114
Hauptverfasser: Obstoy, Bérengère, Salaun, Mathieu, Bohn, Pierre, Veresezan, Liana, Sesboué, Richard, Thiberville, Luc
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cancer
Cell Line, Tumor
Cricetinae
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Female
Heller model
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Life Sciences
Light
Lung cancer
Lung Neoplasms - drug therapy
Lung Neoplasms - pathology
Male
Methylene blue
Methylene Blue - administration & dosage
Mice
Mice, Nude
Mouth Neoplasms - drug therapy
Mouth Neoplasms - pathology
Photochemotherapy - methods
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Treatment Outcome
Tumor Burden - drug effects
Tumor Burden - radiation effects
Xenograft
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Beschreibung
Zusammenfassung:Highlights • Methylene blue (MB) is evaluated as a photodynamic agent for cancer treatment of lung adenocarcinoma xenograft and Hamster cheek pouch induced squamous cell carcinoma. • MB-PDT was performed in-vivo on lung cancer xenograft in nude mice and in the cheek pouch model. • MB-PDT induced a significant decrease of the tumour volume in the two animal models. • In the cheek pouch model, 4 out of 9 had complete response with MB-PDT. • Intratumoral MB is inexpensive and appears efficient as PDT agent.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2016.03.003