Dysfunctional stress responses in chronic pain

Highlights • Many dysfunctional and chronic pain conditions overlap. • Chronic deregulation of the adaptive response to stress may be the common factor. • The HPA axis, neuro-steroids, autonomous nervous and immune systems are implicated. • Individual vulnerability to stress can be due to environmen...

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Veröffentlicht in:	Psychoneuroendocrinology 2016-09, Vol.71, p.127-135
Hauptverfasser:	Woda, Alain, Picard, Pascale, Dutheil, Frédéric
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Autonomic nervous system Chronic Chronic Pain - metabolism Chronic Pain - physiopathology Cognitive science Cushing Syndrome - metabolism Cytokines - immunology Cytokines - metabolism Dehydroepiandrosterone - metabolism Dehydroepiandrosterone Sulfate - metabolism Disease Endocrinology & Metabolism Environment Humans Hypothalamo-Hypophyseal System - metabolism Physiopathology Pituitary-Adrenal System - metabolism Progesterone Psychiatry Psychology Th1 Cells - immunology Th2 Cells - immunology
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Beschreibung
Zusammenfassung:	Highlights • Many dysfunctional and chronic pain conditions overlap. • Chronic deregulation of the adaptive response to stress may be the common factor. • The HPA axis, neuro-steroids, autonomous nervous and immune systems are implicated. • Individual vulnerability to stress can be due to environmental and genetic factors.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.05.017