Circulating Normal IgG as Stimulator of Regulatory T Cells: Lessons from Intravenous Immunoglobulin

Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors’ plasma, is extensively used for the immunotherapy of autoimmune and inflammatory disorders. Recent reports demonstrate that IVIG exerts anti-inflammatory actions by stimulating the activatio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in immunology 2017-11, Vol.38 (11), p.789-792
Hauptverfasser:	Maddur, Mohan S, Kaveri, Srini V., Bayry, Jagadeesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibody Antigen-presenting cells Autoimmune diseases Blood & organ donations Blood Circulation DC-SIGN DCIR Dendritic cells Dendritic Cells - metabolism Guillain-Barre syndrome Homeostasis Humans IL-33 Immunization Immunoglobulin G Immunoglobulin G - immunology Immunoglobulins Immunoglobulins, Intravenous - immunology Immunoglobulins, Intravenous - therapeutic use Immunology Immunoregulation Immunotherapy Inflammation Inflammatory diseases Intravenous administration intravenous immunoglobulin Kawasaki disease Life Sciences Lymphocyte Activation Lymphocytes Lymphocytes T Mice Plasma prostaglandin E2 regulatory T cells Rodents T-Lymphocytes, Regulatory - immunology tregitopes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Intravenous immunoglobulin (IVIG), a pooled normal IgG formulation prepared from thousands of healthy donors’ plasma, is extensively used for the immunotherapy of autoimmune and inflammatory disorders. Recent reports demonstrate that IVIG exerts anti-inflammatory actions by stimulating the activation and expansion of regulatory T (Treg) cells by multiple mechanisms via antigen-presenting cells (APCs).
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2017.08.008