What is currently known about the genetics of venous thromboembolism at the dawn of next generation sequencing technologies

Summary Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE‐associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of haematology 2018-02, Vol.180 (3), p.335-345
Hauptverfasser:	Trégouët, David‐Alexandre, Morange, Pierre‐Emmanuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Cardiology and cardiovascular system Genes Genetic Association Studies Genetic diversity Genetic Loci Genetic Predisposition to Disease Genetic variance Genetic Variation Genetics Genomics - methods Hematology High-Throughput Nucleotide Sequencing Human genetics Human health and pathology Humans Life Sciences next generation sequencing sequencing technologies Thromboembolism venous thromboembolism Venous Thromboembolism - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary Venous thromboembolism (VTE) has a strong genetic component. This review summarizes what is known at the seventeen genes that are now well established to harbour VTE‐associated genetic variants. In addition, it discusses additional candidate genes that deserve further validation before being claimed as VTE associated genes. Finally, several research strategies are briefly described to identify other molecular determinants of the disease.
ISSN:	0007-1048 1365-2141
DOI:	10.1111/bjh.15004